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水中氯对脊髓灰质炎病毒I型(布伦希尔德株)单颗粒的灭活作用。

Inactivation of poliovirus I (Brunhilde) single particles by chlorine in water.

作者信息

Sharp D G, Leong J

出版信息

Appl Environ Microbiol. 1980 Aug;40(2):381-5. doi: 10.1128/aem.40.2.381-385.1980.

DOI:10.1128/aem.40.2.381-385.1980
PMID:6258476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC291585/
Abstract

Like the Mahoney strain, the Brunhilde strain of poliovirus aggregated slowly in dilute phosphate-carbonate buffer at pH 6 but not at all at or above pH 7. Infectivity decreased at rates approximately proportional to the concentration of free chlorine present at pH 6 over the entire range of 5 to 40 micrometer. The addition of 0.1 M NaCl to the buffer increased the rate about twofold, but this strain was still twice as resistant as the Mahoney strain. At pH 10, inactivation was much slower than at pH 6, but when 0.1 M NaCl was added, the rate was increased 31-fold, making the OCl- at pH 10 over three times more effective than HOCl at pH 6.

摘要

与马奥尼毒株一样,脊髓灰质炎病毒的布伦希尔德毒株在pH值为6的稀磷酸盐 - 碳酸盐缓冲液中聚集缓慢,但在pH值为7或更高时则完全不聚集。在pH值为6时,感染力的下降速率在5至40微米的整个范围内大致与游离氯的浓度成正比。向缓冲液中添加0.1 M氯化钠可使速率提高约两倍,但该毒株的抗性仍是马奥尼毒株的两倍。在pH值为10时,灭活速度比在pH值为6时慢得多,但添加0.1 M氯化钠后,速率提高了31倍,使得pH值为10时的次氯酸根离子比pH值为6时的次氯酸有效三倍以上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de81/291585/da488d6437a0/aem00238-0213-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de81/291585/da488d6437a0/aem00238-0213-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de81/291585/da488d6437a0/aem00238-0213-a.jpg

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