Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
Curr Med Chem. 2019;26(25):4852-4884. doi: 10.2174/0929867325666180605124256.
Plant tannins are polyphenolic substances with various molecular weights and a variable complexity. Due to the beneficial effects for controlling chronic disorders particularly diabetes mellitus, this class of secondary metabolites has gained more interest in the recent years.
We aimed through this review to collect, analyze and discuss all available information related to the antidiabetic effect of isolated tannins (including both condensed and hydrolysable varieties) and tannin-rich plants as well as the possible mechanisms of action involved in this antidiabetic activity.
Our bibliographic research was conducted to gather more than 41 medicinal plants containing tannins and 19 isolated tannins and tannin-rich crud extracts which were revealed to possess glucose lowering effect according to pharmacological studies.
Hence, according to findings of the present review, tannins could be useful for prevention and management of diabetes mellitus and its associated complications and these natural products could be promising compounds for the discovery of new hypoglycemic agents.
植物单宁是具有多种分子量和可变复杂性的多酚类物质。由于其对控制慢性疾病（特别是糖尿病）的有益作用，近年来这类次生代谢产物引起了更多的关注。
通过本综述，我们旨在收集、分析和讨论与分离单宁（包括缩合单宁和可水解单宁）和富含单宁的植物的降血糖作用相关的所有可用信息，以及涉及这种降血糖活性的可能作用机制。
我们进行了文献研究，以收集 41 种含有单宁的药用植物和 19 种分离的单宁和富含单宁的粗提取物的信息，这些植物和提取物根据药理学研究显示具有降低血糖的作用。
因此，根据本综述的研究结果，单宁可能有助于预防和治疗糖尿病及其相关并发症，这些天然产物可能是发现新的降血糖药物的有前途的化合物。
