肠-脑轴与情绪障碍
Gut-Brain Axis and Mood Disorder.
作者信息
Liu Lu, Zhu Gang
机构信息
Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
出版信息
Front Psychiatry. 2018 May 29;9:223. doi: 10.3389/fpsyt.2018.00223. eCollection 2018.
Abstract
Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobiochemical, neuroendocrine, and neuroimmune system mechanisms of the gut-brain axis to determine the relationship between intestinal microbiota and mood disorders. The effect of prebiotics, probiotics and antibiotics on mood disorders are also discussed, with the aim to propose some new therapeutic strategies for mood disorders.
摘要
人体内有超过100万亿个细菌，在肠道中高度富集。有证据表明，肠道微生物群与神经-内分泌-免疫途径相关，并可能与各种情绪障碍有关。这篇综述总结了研究肠道-脑轴的神经生化、神经内分泌和神经免疫系统机制的研究结果，以确定肠道微生物群与情绪障碍之间的关系。还讨论了益生元、益生菌和抗生素对情绪障碍的影响，旨在提出一些针对情绪障碍的新治疗策略。
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