人巨细胞病毒诱导的单核细胞衍生白细胞介素1抑制剂
Monocyte-derived inhibitor of interleukin 1 induced by human cytomegalovirus.
作者信息
Rodgers B C, Scott D M, Mundin J, Sissons J G
出版信息
J Virol. 1985 Sep;55(3):527-32. doi: 10.1128/JVI.55.3.527-532.1985.
Abstract
It has previously been shown that human cytomegalovirus (HCMV) can exert immunosuppressive effects, and it has been suggested that these may be mediated by monocytes, although the mechanism is unclear. We showed that infection of human monocytes with the AD169 strain of HCMV abrogates their production of interleukin 1 (IL-1) activity. This was associated with the release from infected monocytes of an inhibitor of IL-1 activity which was also released after HCMV infection of the U937 macrophage-like cell line. The inhibitor of IL-1 activity is a protein with an apparent molecular weight of ca. 95,000. This action of HCMV strain AD169 was virus specific and required infectious virus but occurred without virus replication or detectable expression of viral proteins. This effect may account, at least in part, for the previously observed immunosuppressive properties of HCMV.
摘要
先前已有研究表明，人巨细胞病毒（HCMV）可发挥免疫抑制作用，并且有人提出这些作用可能由单核细胞介导，尽管其机制尚不清楚。我们发现，用HCMV的AD169株感染人单核细胞可消除其白细胞介素1（IL-1）活性的产生。这与受感染单核细胞释放IL-1活性抑制剂有关，U937巨噬细胞样细胞系感染HCMV后也会释放该抑制剂。IL-1活性抑制剂是一种表观分子量约为95,000的蛋白质。HCMV AD169株的这种作用具有病毒特异性，需要有感染性的病毒，但在没有病毒复制或未检测到病毒蛋白表达的情况下即可发生。这种效应可能至少部分解释了先前观察到的HCMV的免疫抑制特性。
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