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糖、寡糖和多糖纳米颗粒在生物医学中的应用。

Saccharides, oligosaccharides, and polysaccharides nanoparticles for biomedical applications.

机构信息

Department of Materials Science and Engineering, School of Molecular Science and Technology, Vidyasirimedhi Institute of Science and Technology, Rayong 21210, Thailand.

Department of Materials Science and Engineering, School of Molecular Science and Technology, Vidyasirimedhi Institute of Science and Technology, Rayong 21210, Thailand.

出版信息

J Control Release. 2018 Aug 28;284:188-212. doi: 10.1016/j.jconrel.2018.06.026. Epub 2018 Jun 27.

Abstract

Modern requirements for designing efficient nanocarriers against diseases such as cancer are very complex. A suitable nanocarrier should indeed remain colloidally stable in the body, be biodegradable, target specific tumor cells, and release efficiently drugs. These challenging tasks can be overcome by using the chemistry of saccharides and polysaccharides. We discuss here recent applications of carbohydrates-based materials for providing biodegradability, enhancing contrast in bioimaging, a stealth effect for controlling the composition of protein corona, and targeting ability.

摘要

现代设计针对癌症等疾病的高效纳米载体的要求非常复杂。合适的纳米载体在体内确实应保持胶体稳定、可生物降解、靶向特定的肿瘤细胞,并能有效地释放药物。这些具有挑战性的任务可以通过使用糖和多糖的化学方法来克服。我们在这里讨论了基于碳水化合物的材料在提供生物降解性、增强生物成像对比度、控制蛋白质冠组成的隐身效果和靶向能力方面的最新应用。

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