Kohli K, Corns R, Vinnakota K, Steiner P, Elith C, Schellenberg D, Kwan W, Karvat A
BC Cancer-Fraser Valley Centre, Surrey, BC.
Brody School of Medicine, East Carolina University, Greenville, North Carolina, U.S.A.
Curr Oncol. 2018 Jun;25(3):e193-e199. doi: 10.3747/co.25.3920. Epub 2018 Jun 28.
Malnutrition is a frequent manifestation in patients with head-and-neck cancer undergoing radiation therapy and a major contributor to morbidity and mortality. Thus, body composition is an important component of an overall evaluation of nutrition in cancer patients. Malnutrition is characterized by weight loss, loss of muscle mass, changes in cell membrane integrity, and alterations in fluid balance. Bioelectrical impedance analysis is a method to analyze body composition and includes parameters such as intracellular water content, extracellular water content, and cell membrane integrity in the form of a phase angle (Φ). Bioelectrical impedance analysis has consistently been shown to have prognostic value with respect to mortality and morbidity in patients undergoing chemotherapy. The goal of the present study was to evaluate the relationship between Φ, time, intracellular water content, and weight for head-and-neck cancer patients undergoing radiotherapy. The results demonstrate that Φ decreases with time and increases with intracellular water content and weight.
营养不良是头颈癌患者接受放射治疗时常见的表现，也是发病率和死亡率的主要促成因素。因此，身体组成是癌症患者营养综合评估的重要组成部分。营养不良的特征包括体重减轻、肌肉量减少、细胞膜完整性改变以及体液平衡改变。生物电阻抗分析是一种分析身体组成的方法，包括细胞内含水量、细胞外含水量以及以相角（Φ）形式表示的细胞膜完整性等参数。生物电阻抗分析一直被证明对接受化疗的患者的死亡率和发病率具有预后价值。本研究的目的是评估接受放疗的头颈癌患者的相角、时间、细胞内含水量和体重之间的关系。结果表明，相角随时间降低，随细胞内含水量和体重增加。
