Hu Shenglan, Wang Yu, Wen Xiaolu, Wang Li, Jiang Zongyong, Zheng Chuntian
Institute of Animal Science, Guangdong Academy of Agricultural Sciences; State Key Laboratory of Livestock and Poultry Breeding; Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture; Guangdong Public Laboratory of Animal Breeding and Nutrition; Guangdong Key Laboratory of Animal Breeding and Nutrition, #1 Dafeng 1st Street, Wushan, Tianhe District, 510640, Guangzhou, Guangdong, People's Republic of China.
Hebei depond animal health care science and technology co., Ltd, #8 shuangtong Road, Mengtong, Luquan District, 050204, Shijiazhuang, Hebei, People's Republic of China.
BMC Vet Res. 2018 Jul 4;14(1):215. doi: 10.1186/s12917-018-1543-8.
Chitosan was used as an alternative to promote the growth of weaned piglets. And low-molecular-weight chitosan (LC) is one of chitosan derivatives and maintain beneficial biological properties of chitoson. The present experiment was carried out to examine the effects of LC on the growth performance, intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets.
A total of 40 piglets weaned at 21 d of age, with average body weight 6.37 ± 0.08 kg, were randomly assigned (5 pens/diet; 4 pigs/pen) to 2 treatments (a basal diet and the basal diet supplemented with 50 mg/kg LC) and were fed for 28 d. Compared with the control group, average daily feed intake (ADFI), and the expression of intestinal barrier protein ZO-1 was increased (P < 0.05) when the piglets fed the diet supplemented with LC. No significant differences were found in average daily gain (ADG, P > 0.05), gain-to-feed ratio (G:F, P > 0.05), the incidence of diarrhea (P > 0.05), or the antioxidant capacity (P > 0.05) between two groups. The expression of IL-1β and TNF-α in jejunal mucosa were significantly decreased (P < 0.05) in piglets fed the LC-supplemented diet in comparison to the control.
The results of this study indicate that dietary supplementation with LC at 50 mg/kg was effective for enhancing the growth performance in weaned piglets, improving intestinal barrier function and alleviating intestinal inflammation.
壳聚糖被用作促进断奶仔猪生长的替代品。低分子量壳聚糖（LC）是壳聚糖衍生物之一，保留了壳聚糖的有益生物学特性。本试验旨在研究LC对断奶仔猪生长性能、肠道形态、屏障功能、细胞因子表达和抗氧化系统的影响。
选取40头21日龄断奶仔猪，平均体重6.37±0.08 kg，随机分为2组（每组5个重复，每个重复4头猪），分别饲喂基础日粮和添加50 mg/kg LC的基础日粮，为期28天。与对照组相比，饲喂添加LC日粮的仔猪平均日采食量（ADFI）和肠道屏障蛋白ZO-1的表达增加（P<0.05）。两组之间的平均日增重（ADG，P>0.05）、料重比（G:F，P>0.05）、腹泻发生率（P>0.05）或抗氧化能力（P>0.05）无显著差异。与对照组相比，饲喂添加LC日粮的仔猪空肠黏膜中IL-1β和TNF-α的表达显著降低（P<0.05）。
本研究结果表明，日粮中添加50 mg/kg LC可有效提高断奶仔猪的生长性能，改善肠道屏障功能，减轻肠道炎症。
