Koukoula Stavroula C, Katsanos Andreas, Tentes Ioannis K, Labiris Georgios, Kozobolis Vassilios P
Department of Ophthalmology, University Hospital of Alexandroupolis, Alexandroupolis, Greece,
Eye Institute of Thrace, Alexandroupolis, Greece,
Clin Ophthalmol. 2018 Jul 2;12:1199-1204. doi: 10.2147/OPTH.S155551. eCollection 2018.
Endothelin-1 (ET-1) is the most potent vasoconstrictor in the body. There are reports in the literature correlating plasma levels of ET-1 and its impact on retrobulbar hemodynamics. This study evaluates aqueous humor levels of ET-1 and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG).
Patients scheduled for cataract surgery were included. Patients were allocated to non-exfoliation non-glaucoma group (controls), XFG and XFS groups. Peak systolic velocity (PSV), end diastolic velocity, and resistivity index of the ophthalmic artery (OA), short posterior ciliary arteries, and central retinal artery (CRA) were determined preoperatively using color Doppler imaging. Aqueous humor samples obtained at the beginning of cataract surgery were analyzed with enzyme-linked immunosorbent assay.
Sixty-nine participants of similar age were included (controls: n=24, XFG: n=22, XFS: n=23). Multiple regression analysis showed that ET-1, OA-PSV, OA-resistivity index, CRA-PSV, and CRA-end diastolic velocity were influenced by group but not by sex or age. ET-1 for the XFG group (15.93±2.8 pg/mL) was significantly higher than for the XFS (8.92±2.7 pg/mL) and control (8.44±2.6 pg/mL) groups. The difference in ET-1 titers between the control and XFS groups was not statistically significant. All four hemodynamic parameters affected by group status significantly correlated with ET-1 levels in eyes with XFS. In eyes with XFG, two of the four hemodynamic parameters significantly correlated with ET-1 levels. In control eyes, no correlation between ET-1 and hemodynamic parameters affected by group status was detected.
ET-1 aqueous levels in eyes with XFG were significantly higher than those of age-matched controls. Reduced blood flow and increased vascular resistivity were detected in the OA and the CRA in eyes with XFG/XFS. ET-1 levels in eyes with XFG/XFS exhibit a significant correlation with hemodynamic parameters that indicate reduced perfusion.
内皮素 -1（ET-1）是体内最有效的血管收缩剂。文献中有报道将ET-1的血浆水平与其对球后血流动力学的影响相关联。本研究评估了剥脱综合征（XFS）和剥脱性青光眼（XFG）患者房水中ET-1的水平及球后血流动力学情况。
纳入计划进行白内障手术的患者。将患者分为非剥脱性非青光眼组（对照组）、XFG组和XFS组。术前使用彩色多普勒成像测定眼动脉（OA）、睫状后短动脉和视网膜中央动脉（CRA）的收缩期峰值速度（PSV）、舒张末期速度和阻力指数。在白内障手术开始时采集的房水样本采用酶联免疫吸附测定法进行分析。
纳入了69名年龄相仿的参与者（对照组：n = 24，XFG组：n = 22，XFS组：n = 23）。多元回归分析显示，ET-1、OA-PSV、OA阻力指数、CRA-PSV和CRA舒张末期速度受组别影响，但不受性别或年龄影响。XFG组的ET-1（15.93±2.8 pg/mL）显著高于XFS组（8.92±2.7 pg/mL）和对照组（8.44±2.6 pg/mL）。对照组和XFS组之间ET-1滴度的差异无统计学意义。受组别状态影响的所有四个血流动力学参数与XFS眼中的ET-1水平显著相关。在XFG眼中，四个血流动力学参数中的两个与ET-1水平显著相关。在对照眼中，未检测到ET-1与受组别状态影响的血流动力学参数之间的相关性。
XFG眼中的ET-1房水水平显著高于年龄匹配的对照组。在XFG/XFS眼中，检测到OA和CRA的血流减少且血管阻力增加。XFG/XFS眼中的ET-1水平与表明灌注减少的血流动力学参数呈显著相关。
