Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Sci Rep. 2018 Jul 12;8(1):10566. doi: 10.1038/s41598-018-28646-w.
Novel prognostic inflammatory markers of cancer survival and cardiovascular disease are; the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR) and the systemic immune-inflammation index (SII). As normal values for these markers are unknown, our objective was to obtain reference values in the general population. We obtained data from a population-based prospective cohort study of individuals aged 45 years and over between 2002 and 2014. Absolute blood counts were used to calculate the NLR, PLR and SII. All inflammatory indices followed a log-normal distribution. We calculated the mean and 95% reference intervals in an unselected population. Furthermore we studied whether the inflammatory markers differed between age categories and gender. In total 8,711 participants (57.1% female; mean age 65.9 years, standard deviation 10.5 years) were included. Mean values and corresponding 95% reference intervals for the NLR were: 1.76 (0.83-3.92), for PLR: 120 (61-239) and for SII: 459 (189-1168). The inflammatory markers increased with age. The PLR and SII were higher in females, whilst the NLR was higher in males. In conclusion, we provided reference values for new inflammatory markers. All increase with age and vary with gender. This provides context that allows for proper interpretation of their potential value in future clinical practice and research.
新型癌症生存和心血管疾病预后炎症标志物包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SII）。由于这些标志物的正常值未知，我们的目标是在一般人群中获得参考值。我们从 2002 年至 2014 年间一项针对 45 岁及以上人群的基于人群的前瞻性队列研究中获取数据。绝对血细胞计数用于计算 NLR、PLR 和 SII。所有炎症指数均呈对数正态分布。我们在未选择的人群中计算了平均值和 95%参考区间。此外，我们还研究了炎症标志物是否在年龄类别和性别之间存在差异。共有 8711 名参与者（57.1%为女性；平均年龄 65.9 岁，标准差为 10.5 岁）被纳入研究。NLR 的平均值和相应的 95%参考区间为：1.76（0.83-3.92），PLR 为 120（61-239），SII 为 459（189-1168）。炎症标志物随年龄增长而增加。女性的 PLR 和 SII 较高，而男性的 NLR 较高。总之，我们提供了新型炎症标志物的参考值。所有标志物均随年龄增长而增加，且性别不同。这为它们在未来临床实践和研究中的潜在价值的正确解释提供了背景。
