Academic Rheumatology, Faculty of Life Sciences and Medicine, London, UK.
Psychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Rheumatology (Oxford). 2019 Jan 1;58(1):45-51. doi: 10.1093/rheumatology/key240.
The Musculoskeletal Health Questionnaire (MSK-HQ) is a recently developed Patient Reported Outcome Measure for use across patients with musculoskeletal conditions. This study provides a validation of the MSK-HQ examining construct validity and reliability in inflammatory arthritis.
287 adults with inflammatory arthritis completed the MSK-HQ and other Patient Reported Outcome Measures at baseline and after 3 months. Construct validity was assessed using item response theory methods. Concurrent validity was considered in relation to the HAQ and EuroQol-5D in all patients, as well as the RA Impact of Disease (RAID), PsA Impact of Disease scales, and AS Quality of Life Questionnaire (ASQoL) in disease subtypes.
The MSK-HQ was approximately normally distributed with no evidence of floor or ceiling effects. A unidimensional structure was confirmed. Two items were less weakly related to the latent musculoskeletal health variable, providing some evidence of multidimensionality. Reliability was high (α = 0.93). The total score correlated highly with the HAQ (r = -0.81) and EuroQol-5D index (r = 0.80) in all patients, RAID in RA patients (r = -0.88), PsA Impact of Disease in PsA patients (r = -0.88), and ASQoL in AS patients (r = -0.86). Test-retest reliability was high (rICC = 0.73).
This study provides evidence for the validity and reliability of the MSK-HQ in people with inflammatory arthritis. The major advantage of the MSK-HQ is that it is not disease specific and has high content validity in rheumatological conditions. The MSK-HQ score will be of value in clinical rheumatology practice, providing a measure that can be used across disease areas.
肌肉骨骼健康问卷（MSK-HQ）是一种最近开发的患者报告结局测量工具，适用于各种肌肉骨骼疾病患者。本研究旨在验证 MSK-HQ 在炎症性关节炎中的结构效度和信度。
287 名炎症性关节炎患者在基线和 3 个月后完成了 MSK-HQ 和其他患者报告结局测量。采用项目反应理论方法评估结构效度。在所有患者中，同时考虑了与 HAQ 和 EuroQol-5D 的相关性，以及疾病亚型的 RA 疾病影响（RAID）、PsA 疾病影响量表和 AS 生活质量问卷（ASQoL）的相关性。
MSK-HQ 呈近似正态分布，无地板或天花板效应。确认了单维结构。有两个项目与潜在的肌肉骨骼健康变量的相关性较弱，这提供了多维性的一些证据。信度较高（α=0.93）。总分与 HAQ（r=-0.81）和 EuroQol-5D 指数（r=-0.80）在所有患者中高度相关，在 RA 患者中与 RAID（r=-0.88）、在 PsA 患者中与 PsA 疾病影响量表（r=-0.88）、在 AS 患者中与 ASQoL（r=-0.86）高度相关。测试-重测信度较高（rICC=0.73）。
本研究为炎症性关节炎患者的 MSK-HQ 的有效性和可靠性提供了证据。MSK-HQ 的主要优势在于它不是针对特定疾病的，并且在风湿病学中有很高的内容效度。MSK-HQ 评分将在临床风湿病学实践中具有价值，提供一种可用于多个疾病领域的测量工具。
