从红树林植物中分离出的内生真菌 产生的聚酮化合物
Polyketides From the Endophytic Fungus sp. Isolated From the Mangrove Plant .
作者信息
Wang Liping, Han Xiuli, Zhu Guoliang, Wang Yi, Chairoungdua Arthit, Piyachaturawat Pawinee, Zhu Weiming
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
出版信息
Front Chem. 2018 Aug 14;6:344. doi: 10.3389/fchem.2018.00344. eCollection 2018.
Five new polyketides (-) and ten known compounds ( and -) were obtained from the fermentation products of the endophytic fungus sp. OUCMDZ-302 with the mangrove plant, (Euphorbiaceae). The new structures of - were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound showed cytotoxicity against H1975 cell line with an IC value of 10.0 μM. Compounds and - showed radical scavenging activity against DPPH with the IC values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds - in this paper.
从内生真菌OUCMDZ-302与红树林植物海漆（大戟科）的发酵产物中获得了5个新的聚酮化合物（-）和10个已知化合物（和-）。-的新结构是基于电子圆二色谱（ECD）、比旋度、光谱数据以及化学计算确定的。化合物对H1975细胞系显示出细胞毒性，IC值为10.0 μM。化合物和-对二苯基苦味酰基自由基（DPPH）显示出自由基清除活性，IC值分别为2.65、0.24、5.66和6.67 μM。此外，本文首次通过X射线以及酸性水解产物的糖分析确定了化合物的绝对构型，以及化合物-的绝对构型。
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