Department of Radiology, Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School , Nanjing 210008 , China.
ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31947-31958. doi: 10.1021/acsami.8b10564. Epub 2018 Sep 13.
Designing a smart nanotheranostic system has recently attracted tremendous attention and is highly desirable for realizing targeted cancer therapy and early diagnosis. Herein we report the fabrication of smart nanotheranostic system using multiresponsive gatekeeping protocol of mesoporous silica nanoparticles (MSN). Acid, oxidative stress and redox sensitive manganese oxide (MnO ) coated superparamagnetic iron oxide nanoparticle (SPION) were employed as nanolids to regulate the camptothecin drug release from the channels of mesoporous silica and achieve responsive dual-mode MRI contrast. The nonvehicle showed high magnetization and T2 contrast in magnetic resonance imaging (MRI) due to the significant density of SPION onto the surface of MSN, and at the same time the MnO shell degradation release Mn which enhanced the T1MRI visualization. The efficacy of responsive drug delivery system was investigated on pancreatic cancer cells and tumor-bearing mice, and results reinforced that MnO -SPION@MSN@CPT nonvehicle is efficacious against cancer cells. We envision that our unique and multiresponsive nanoplatform may find applications in effective delivering of imaging and therapeutic agents to wide range of diseases besides cancer.
设计智能纳米治疗系统最近引起了极大的关注，对于实现靶向癌症治疗和早期诊断非常理想。本文报道了一种使用介孔硅纳米粒子（MSN）的多响应门控协议来制备智能纳米治疗系统的方法。酸、氧化应激和氧化还原敏感的氧化锰（MnO）包覆超顺磁性氧化铁纳米粒子（SPION）被用作纳米载体，以调节喜树碱药物从介孔硅通道中的释放，并实现响应性双模磁共振成像（MRI）对比。由于 MSN 表面上 SPION 的密度很大，非载体在磁共振成像（MRI）中表现出高磁化强度和 T2 对比，同时 MnO 壳的降解释放 Mn，增强了 T1MRI 可视化。在胰腺癌细胞和荷瘤小鼠上研究了响应性药物输送系统的疗效，结果表明，MnO-SPION@MSN@CPT 非载体对癌细胞有效。我们设想，我们独特的多响应纳米平台除了癌症之外，还可能在广泛的疾病中有效地输送成像和治疗剂。
