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儿童和青少年注意缺陷/多动障碍(ADHD)既往诊断后孤独症谱系障碍的延迟识别。

Delayed autism spectrum disorder recognition in children and adolescents previously diagnosed with attention-deficit/hyperactivity disorder.

机构信息

Department of Clinical, Neuro & Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Autism. 2019 May;23(4):1065-1072. doi: 10.1177/1362361318785171. Epub 2018 Sep 24.

Abstract

Phenotypic elements of autism spectrum disorder can be masked by attention-deficit/hyperactivity disorder symptoms, potentially leading to a misdiagnosis or delaying an autism spectrum disorder diagnosis. This study explored differences in the age of autism spectrum disorder diagnosis between participants with previously diagnosed attention-deficit/hyperactivity disorder versus autism spectrum disorder-only respondents. Children and adolescents, but not adults, initially diagnosed with attention-deficit/hyperactivity disorder received an autism spectrum disorder diagnosis an average of 1.8 years later than autism spectrum disorder-only children, although the findings regarding the adult sample should be interpreted with caution. Gender differences were also explored, revealing that the delay in receiving an autism diagnosis was 1.5 years in boys and 2.6 years in girls with pre-existing attention-deficit/hyperactivity disorder, compared with boys and girls without prior attention-deficit/hyperactivity disorder. No significant gender differences were observed in the adult sample. We argue that overlapping symptoms between autism spectrum disorder and attention-deficit/hyperactivity disorder might delay a formal diagnosis of autism either by leading to a misdiagnosis of attention-deficit/hyperactivity disorder or by making it difficult to identify the presence of co-occurring autism spectrum disorder conditions once an initial diagnosis of attention-deficit/hyperactivity disorder has been obtained. Current findings highlight the need to recruit multidimensional and multidisciplinary screening procedures to assess for potential emerging autism spectrum disorder hallmarks in children and adolescents diagnosed or presenting with attention-deficit/hyperactivity disorder symptoms.

摘要

自闭症谱系障碍的表型特征可能会被注意力缺陷/多动障碍的症状所掩盖,从而导致误诊或延迟自闭症谱系障碍的诊断。本研究探讨了先前被诊断为注意力缺陷/多动障碍的参与者与仅被诊断为自闭症谱系障碍的参与者之间自闭症谱系障碍诊断年龄的差异。儿童和青少年(但不是成年人)最初被诊断为注意力缺陷/多动障碍,比仅被诊断为自闭症谱系障碍的儿童平均晚 1.8 年接受自闭症谱系障碍诊断,尽管关于成年样本的发现应谨慎解释。研究还探讨了性别差异,结果表明,患有先前注意力缺陷/多动障碍的男孩和女孩接受自闭症诊断的延迟时间分别为 1.5 年和 2.6 年,而没有先前注意力缺陷/多动障碍的男孩和女孩则没有。在成年样本中未观察到显著的性别差异。我们认为,自闭症谱系障碍和注意力缺陷/多动障碍之间的重叠症状可能会导致自闭症的正式诊断延迟,其原因可能是误诊为注意力缺陷/多动障碍,也可能是在最初诊断为注意力缺陷/多动障碍后,难以识别同时存在的自闭症谱系障碍。目前的研究结果强调需要招募多维和多学科的筛选程序,以评估被诊断或出现注意力缺陷/多动障碍症状的儿童和青少年中潜在的自闭症谱系障碍特征。

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