State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211816, People's Republic of China.
Department of Biology, College of Natural and Computational Science, Mizan-Tepi University, P.O.Box 121, Tepi, Ethiopia.
Appl Microbiol Biotechnol. 2018 Dec;102(23):9893-9910. doi: 10.1007/s00253-018-9379-5. Epub 2018 Sep 26.
Due to environmental issues and the depletion of fossil-based resources, ecofriendly sustainable biomass-based chemical production has been given more attention recently. Succinic acid (SA) is one of the top value added bio-based chemicals. It can be synthesized through microbial fermentation using various waste steam bioresources. Production of chemicals from waste streams has dual function as it alleviates environmental concerns; they could have caused because of their improper disposal and transform them into valuable products. To date, Actinobacillus succinogenes is termed as the best natural SA producer. However, few reviews regarding SA production by A. succinogenes were reported. Herewith, pathways and metabolic engineering strategies, biomass pretreatment and utilization, and process optimization related with SA fermentation by A. succinogenes were discussed in detail. In general, this review covered vital information including merits, achievements, progresses, challenges, and future perspectives in SA production using A. succinogenes. Therefore, it is believed that this review will provide platform to understand the potential of the strain and tackle existing hurdles so as to develop superior strain for industrial applications. It will also be used as a baseline for identification, isolation, and improvement of other SA-producing microbes.
由于环境问题和化石基资源的枯竭，最近人们越来越关注环保可持续的生物质基化学品生产。琥珀酸（SA）是最有价值的生物基化学品之一。它可以通过利用各种废生物质资源的微生物发酵来合成。利用废物流生产化学品具有双重功能，既缓解了环境问题，又避免了因处理不当而造成的环境问题，同时将其转化为有价值的产品。迄今为止，多杀巴斯德氏菌被认为是生产 SA 的最佳天然菌。然而，目前关于多杀巴斯德氏菌生产 SA 的综述报道较少。本文详细讨论了多杀巴斯德氏菌发酵生产 SA 的途径和代谢工程策略、生物量预处理和利用，以及过程优化。总的来说，本综述涵盖了使用多杀巴斯德氏菌生产 SA 的重要信息，包括优点、成就、进展、挑战和未来展望。因此，相信本综述将为了解该菌株的潜力和解决现有障碍提供一个平台，从而开发出用于工业应用的优良菌株。它也将作为鉴定、分离和改进其他生产 SA 的微生物的基础。
