Department of Morphology and Pathology, Post-Graduate Program in Evolutionary Genetics and Molecular Biology, Federal University of São Carlos (UFSCar), Rod. Washington Luis, Km 235., Sao Carlos, Sao Paulo, 13565-905, Brazil.
Research and Education Center for Phototherapy in Health Sciences (NUPEN), Sao Carlos, SP, Brazil.
Lasers Med Sci. 2018 Dec;33(9):1841-1848. doi: 10.1007/s10103-018-2653-z. Epub 2018 Oct 6.
Bone defects following trauma represent a high impact on the quality of life of millions of people around the world. The aim of this study was to review photobiomodulation (PBM) action in the treatment of bone critical defects in rat calvaria, related to evaluation of the current protocols applied. One hundred and forty-seven articles related to the subject were found by searching the main databases (Pubmed, Lilacs, Web of Science, and Scopus) considering the period of publication until the year 2017, and only 14 corresponded the inclusion criteria established for this systematic review. The main parameters of the PBM were expressed in Table 1. In addition, it was possible to observe the use of two different wavelengths (red and infrared), which are considered therapeutic. Most of the evaluated articles presented positive results that describe a greater amount of neoformed bone, an increase in collagen synthesis, and a contribution to microvascular reestablishment. However, two studies report no effect on the repair process when the PBM was used. In addition, we observed considerable variations between the values of power, fluence, and total energy, which make it difficult to compare the results presented between the selected studies. It was possible to conclude that the infrared laser was more effective in positively stimulating the bone repair process of critical defects. Furthermore, a discrepancy was found in the parameter values used, which made it difficult to choose the best protocol for the treatment of this type of lesion.
创伤后骨缺损给全世界数以百万计的人的生活质量带来了巨大影响。本研究旨在综述光生物调节（PBM）在治疗大鼠颅骨临界骨缺损中的作用，评估当前应用的方案。通过检索主要数据库（PubMed、Lilacs、Web of Science 和 Scopus），在 2017 年之前的时间段内共找到了 147 篇与该主题相关的文章，仅有 14 篇符合本系统综述的纳入标准。PBM 的主要参数在表 1 中表示。此外，还观察到使用了两种不同的波长（红色和红外线），这两种波长被认为是治疗性的。大多数评估的文章都呈现了积极的结果，描述了更多的新生骨、胶原蛋白合成的增加以及对微血管重建的贡献。然而，有两项研究报告称 PBM 的使用对修复过程没有影响。此外，我们还观察到功率、剂量和总能量之间存在相当大的差异，这使得很难比较所选研究之间呈现的结果。可以得出结论，红外激光在积极刺激临界骨缺损的骨修复过程方面更有效。此外，还发现使用的参数值存在差异，这使得难以选择治疗这种类型病变的最佳方案。
