Zhang Yong-Guo, Xia Yinglin, Lu Rong, Sun Jun
Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois, Chicago, IL, 60612, USA.
Genes Dis. 2018 Jul 11;5(3):220-225. doi: 10.1016/j.gendis.2018.07.001. eCollection 2018 Sep.
Fish oil is a natural product that has shown efficacy for managing inflammatory conditions with few side effects. There is emerging evidence that crosstalks between gut epithelial cells and immune cells contribute to chronic infectious diseases. HIV-infected (HIV+) older adults show age-related co-morbidities at a younger age than their uninfected counterparts. Persistent inflammation related to the chronic viral infection and its sequelae is thought to contribute to this disparity. However, little is known about whether fish oil reduces intestinal inflammation in HIV + patients. We measure inflammation and gut barrier function in HIV + older adults (median age = 52, N = 33), following 12 weeks of fish oil supplementation (a total daily dose of 1.6 g of omega-3 fatty acids). We showed a reduction in inflammation and gut permeability as measured by CD14, inflammatory cytokines, lipopolysaccharide, and lipopolysaccharide binding protein. The results indicate that older HIV + adults may benefit from a diet supplemented with the omega-3 fatty acids found in fish oil.
鱼油是一种天然产品，已显示出在治疗炎症性疾病方面具有疗效，且副作用较少。越来越多的证据表明，肠道上皮细胞与免疫细胞之间的相互作用会导致慢性传染病。感染HIV（HIV+）的老年人比未感染的同龄人在更年轻的时候就出现与年龄相关的合并症。与慢性病毒感染及其后遗症相关的持续性炎症被认为是造成这种差异的原因。然而，关于鱼油是否能减轻HIV+患者的肠道炎症，人们知之甚少。我们对33名年龄中位数为52岁的HIV+老年人进行了为期12周的鱼油补充（每日总剂量为1.6克ω-3脂肪酸），之后测量了他们的炎症和肠道屏障功能。通过CD14、炎性细胞因子、脂多糖和脂多糖结合蛋白测量，我们发现炎症和肠道通透性有所降低。结果表明，年龄较大的HIV+成年人可能会从补充鱼油中含有的ω-3脂肪酸的饮食中受益。
