人乳头瘤病毒18型DNA整合于宫颈癌细胞系SW756的单个染色体位点。
Human papillomavirus type 18 DNA is integrated at a single chromosome site in cervical carcinoma cell line SW756.
作者信息
Popescu N C, Amsbaugh S C, DiPaolo J A
出版信息
J Virol. 1987 May;61(5):1682-5. doi: 10.1128/JVI.61.5.1682-1685.1987.
Abstract
SW756, a cervical carcinoma cell line, has multiple copies of human papillomavirus type 18 DNA sequences. The integration site of human papillomavirus type 18 DNA was localized by in situ hybridization to chromosome 12 at band q13. This single integration site corresponds to a heritable fragile site, which may have facilitated the integration of the viral DNA.
摘要
SW756是一种宫颈癌细胞系，含有多拷贝的人乳头瘤病毒18型（HPV-18）DNA序列。通过原位杂交将HPV-18 DNA的整合位点定位到12号染色体q13带。这个单一的整合位点对应于一个可遗传的脆性位点，这可能促进了病毒DNA的整合。
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