IEEE Trans Biomed Circuits Syst. 2018 Dec;12(6):1256-1266. doi: 10.1109/TBCAS.2018.2876069. Epub 2018 Oct 15.
Recording neural activity in live animals in vivo with minimal tissue damage is one of the major barriers to understanding the nervous system. This paper presents the technology for a tetherless opto-electronic neural interface based on 180 nm CMOS circuits, heterogeneously integrated with an AlGaAs diode that functions as both a photovoltaic and light emitting diode. These microscale opto-electrically transduced electrodes (MOTEs) are powered by and communicate through an optical interface, simultaneously enabling high temporal-resolution electrical measurements without a tether or a bulky RF coil. The MOTE presented here is 250 μm × 57 μm, consumes 1 μW of electrical power, and is capable of capturing and encoding neural signals before transmitting the encoded signals. The measured noise floor is as low as 15 μV at a 15 kHz bandwidth.
在活体动物中记录神经活动，同时将组织损伤最小化，这是理解神经系统的主要障碍之一。本文提出了一种基于 180nmCMOS 电路的无束缚光电子神经接口技术，该技术与作为光电二极管和发光二极管的 AlGaAs 二极管混合集成。这些微尺度光电转换电极（MOTEs）由光接口供电并通过光接口进行通信，同时能够在没有导联或笨重射频线圈的情况下实现高时间分辨率的电测量。本文提出的 MOTEs 尺寸为 250μm×57μm，功耗为 1μW，能够在传输编码信号之前捕获和编码神经信号。在 15kHz 的带宽下，测量到的噪声底仅为 15μV。
