Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing, 100190, P. R. China.
School of Life Science and Technology, Harbin Institute of Technology, 2 Yikuang Road, Nangang District, Harbin, 150001, P. R. China.
Adv Mater. 2019 Nov;31(45):e1805033. doi: 10.1002/adma.201805033. Epub 2018 Oct 21.
The rapid development of microfluidics technology has promoted new innovations in materials science, particularly by interacting with biological systems, based on precise manipulation of fluids and cells within microscale confinements. This article reviews the latest advances in microfluidics-based biomaterials and biodevices, highlighting some burgeoning areas such as functional biomaterials, cell manipulations, and flexible biodevices. These areas are interconnected not only in their basic principles, in that they all employ microfluidics to control the makeup and morphology of materials, but also unify at the ultimate goals in human healthcare. The challenges and future development trends in biological application are also presented.
微流控技术的快速发展推动了材料科学的新创新，特别是通过在微尺度限制内精确操纵流体和细胞与生物系统相互作用。本文综述了基于微流控的生物材料和生物器件的最新进展，重点介绍了一些新兴领域，如功能生物材料、细胞操作和柔性生物器件。这些领域不仅在其基本原理上相互关联，即它们都采用微流控技术来控制材料的组成和形态，而且在人类医疗保健的最终目标上也实现了统一。还提出了生物应用中的挑战和未来发展趋势。
