Yamaleyeva Liliya M, Brosnihan K Bridget, Smith Lane M, Sun Yao
1 Department of Surgery, Hypertension and Vascular Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
2 Department of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Mol Imaging. 2018 Jan-Dec;17:1536012118802721. doi: 10.1177/1536012118802721.
Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimensional photoacoustic imaging (PAI) for assessment of regional variations in placental oxygenation and longitudinal analysis of differences in placental oxygenation throughout normal pregnancy and pregnancy associated with hypertension or placental insufficiency in mice. Three-dimensional PAI more accurately reflects oxygen saturation, hemoglobin concentrations, and changes in oxygen saturation in whole placenta compared to 2-dimensional imaging. These studies suggest that PAI is a sensitive tool to detect different levels of oxygen saturation in the placental and fetal vasculature in pathologic and normal pregnancy in mice.
胎盘氧合在整个孕期会有所变化。随着孕期进展，检测胎盘氧合的早期变化对于子痫前期或其他并发症的早期识别很重要。这篇特邀评论讨论了一项近期的临床前研究，该研究应用三维光声成像（PAI）评估胎盘氧合的区域差异，并对正常妊娠以及小鼠中与高血压或胎盘功能不全相关的妊娠期间胎盘氧合差异进行纵向分析。与二维成像相比，三维PAI能更准确地反映整个胎盘的氧饱和度、血红蛋白浓度以及氧饱和度变化。这些研究表明，PAI是检测小鼠病理妊娠和正常妊娠中胎盘及胎儿血管系统不同氧饱和度水平的灵敏工具。
