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LogMPIE,使用 16S rRNA 测序对全印度人类肠道微生物组进行的分析。

LogMPIE, pan-India profiling of the human gut microbiome using 16S rRNA sequencing.

机构信息

Innovation Center, Tata Chemicals Ltd, Ambedveth, Pune, Maharashtra, 412111, India.

Thermo Fisher Scientific, Invitrogen BioServices India Pvt Ltd, Mumbai, Maharashtra, 400076, India.

出版信息

Sci Data. 2018 Oct 30;5:180232. doi: 10.1038/sdata.2018.232.

Abstract

The "Landscape Of Gut Microbiome - Pan-India Exploration", or LogMPIE study, is the first large-scale, nationwide record of the Indian gut microbiome. The primary objective of the study was to identify and map the Indian gut microbiome baseline. This observational study was conducted across 14 geographical locations in India. Enrolled subjects were uniformly distributed across geographies (north, east, west and south) and body mass index (obese and non-obese). Furthermore, factors influencing the microbiome, such as age and physical activity, were also considered in the study design. The LogMPIE study recorded data from 1004 eligible subjects and reported 993 unique microorganisms across the Indian microbiome diaspora. The data not only map the Indian gut microbiome baseline but also function as a useful resource to study, analyse and identify signatures characterizing the physiological dispositions of the subjects. Furthermore, they provide insight into the unique features describing the Indian microbiome. The data are open and may be accessed from the European Nucleotide Archive (ENA) portal of the European Bioinformatics Institute (https://www.ebi.ac.uk/ena/data/view/PRJEB25642).

摘要

“肠道微生物组全景-全印度探索”(Landscape Of Gut Microbiome - Pan-India Exploration),简称 LogMPIE 研究,是对印度肠道微生物组的首次大规模全国性记录。该研究的主要目的是确定和绘制印度肠道微生物组基线。这项观察性研究在印度的 14 个地理位置进行。入组的受试者在地理位置(北部、东部、西部和南部)和体重指数(肥胖和非肥胖)上均匀分布。此外,研究设计还考虑了影响微生物组的因素,如年龄和身体活动。LogMPIE 研究记录了来自 1004 名合格受试者的数据,并报告了印度微生物组散居地的 993 种独特微生物。这些数据不仅绘制了印度肠道微生物组基线,而且还可作为研究、分析和识别描述受试者生理特征的特征的有用资源。此外,它们还深入了解描述印度微生物组的独特特征。这些数据是开放的,可从欧洲生物信息研究所(European Bioinformatics Institute)的欧洲核苷酸档案(European Nucleotide Archive,ENA)门户(https://www.ebi.ac.uk/ena/data/view/PRJEB25642)访问。

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