烟曲霉对宿主防御的抑制作用。
Suppression of host defences by Aspergillus fumigatus.
作者信息
Robertson M D, Seaton A, Milne L J, Raeburn J A
出版信息
Thorax. 1987 Jan;42(1):19-25. doi: 10.1136/thx.42.1.19.
Abstract
An important feature of the microbicidal action of phagocytic cells is their ability to produce reactive oxygen intermediates. In an attempt to identify the mechanisms by which the fungus Aspergillus fumigatus resists normal host defences the effect of spores and spore diffusates of A fumigatus on the production of superoxide anion and hydrogen peroxide by primed rodent phagocytic cells has been measured. For comparison we have used the non-pathogenic fungus Penicillium ochrochloron. Production of these reactive oxygen intermediates in response to A fumigatus was significantly lower than that in response to P ochrochloron. A similar reduction was achieved by diffusate prepared from freshly washed spores. The inhibitory component was of low molecular weight (less than 14,000) and its effect was dose dependent. These results suggest that spores of A fumigatus fail to trigger and also inhibit the production of reactive oxygen intermediates by phagocytic cells.
摘要
吞噬细胞杀菌作用的一个重要特征是它们产生活性氧中间体的能力。为了确定烟曲霉抵抗正常宿主防御的机制，已测量了烟曲霉的孢子和孢子扩散物对经预处理的啮齿动物吞噬细胞产生超氧阴离子和过氧化氢的影响。为作比较，我们使用了非致病性真菌黄绿青霉。对烟曲霉产生的这些活性氧中间体的量明显低于对黄绿青霉产生的量。用刚洗涤过的孢子制备的扩散物也能产生类似的降低效果。抑制成分分子量低（小于14,000），其作用呈剂量依赖性。这些结果表明，烟曲霉的孢子不能触发并抑制吞噬细胞产生活性氧中间体。
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