Robertson M D, Seaton A, Milne L J, Raeburn J A
Institute of Occupational Medicine, Edinburgh.
Thorax. 1987 Jun;42(6):466-72. doi: 10.1136/thx.42.6.466.
Phagocytic cells are believed to have an important role in the eradication of fungal spores from the lung. The ability of human and mouse cells to phagocytose the opportunistic fungus Aspergillus fumigatus has been examined, spores of the non-pathogenic fungus Penicillium ochrochloron being used for comparison. Most spores became associated with cells. Those of A fumigatus appeared to remain bound to the surface of the phagocyte rather than being ingested; in contrast, P ochrochloron spores appeared to be phagocytosed more readily, although they also were seen, in small numbers, o n the cell surface. In view of the subjective nature of these observations, the effects of spore diffusates on phagocytosis were examined. Diffusates from spores of A fumigatus were shown to inhibit phagocytosis of antibody coated radiolabelled sheep red blood cells by primed mouse phagocytic cells. Diffusates of spores of P ochrochloron had no such effect. These results suggest that when spores of A fumigatus become bound to the surface of phagocytes they are able to release a substance that inhibits their ingestion while having little or no effect on surface binding.
吞噬细胞被认为在清除肺部真菌孢子方面发挥着重要作用。研究了人和小鼠细胞吞噬机会性真菌烟曲霉的能力，并使用非致病性真菌黄绿青霉的孢子进行比较。大多数孢子与细胞相关联。烟曲霉的孢子似乎仍附着在吞噬细胞表面而未被吞噬；相比之下，黄绿青霉的孢子似乎更容易被吞噬，尽管也有少量孢子出现在细胞表面。鉴于这些观察结果具有主观性，因此研究了孢子扩散物对吞噬作用的影响。结果表明，烟曲霉孢子的扩散物可抑制致敏小鼠吞噬细胞对抗体包被的放射性标记绵羊红细胞的吞噬作用。黄绿青霉孢子的扩散物则没有这种作用。这些结果表明，当烟曲霉的孢子与吞噬细胞表面结合时，它们能够释放一种物质，这种物质会抑制孢子被吞噬，而对表面结合作用很小或没有影响。
