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成瘾行为的心理和遗传因素(PGA)研究。

The psychological and genetic factors of the addictive behaviors (PGA) study.

机构信息

Department of Clinical Psychology and Addiction, Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

Postdoctoral Research Program, Hungarian Academy of Sciences, Budapest, Hungary.

出版信息

Int J Methods Psychiatr Res. 2019 Mar;28(1):e1748. doi: 10.1002/mpr.1748. Epub 2018 Nov 6.

Abstract

OBJECTIVES

Most of the addiction studies focus on very specific aspects of addictions, often with contradictory results, and integrated studies are quite rare. Experimental studies comparing underlying mechanisms of addictions and analyzing data from an integrative psychological and genetic perspective are almost nonexistent. The aim of the present paper is to describe the research protocol of the Psychological and Genetic Factors of Addictive Behaviors (PGA) study, which applies an integrative approach to understanding the acquisition, development, and maintenance of addictive behaviors.

METHODS

A wide-spectrum national study was carried out. Data were collected from 3,003 adolescents. Addictions to both psychoactive substances and behaviors were thoroughly assessed via psychometrically robust scales, which also included assessment related to a wide range of related psychological dimensions. Additionally, a DNA sample was also collected from participants.

RESULTS

The paper presents the detailed methodology of the PGA study. Data collection procedures, instrumentation, and the analytical approach used to attain the research objectives are described.

CONCLUSIONS

Future plans, along with potential contributions of the PGA study, are also discussed. It is envisaged that the study will provide a unique opportunity to test possible mechanisms and causal pathways mediating the associations of genetic factors, psychological characteristics, and addictions.

摘要

目的

大多数成瘾研究都集中在成瘾的非常特定的方面,结果往往相互矛盾,综合性研究相当罕见。比较成瘾的潜在机制的实验研究和从综合心理和遗传角度分析数据的研究几乎不存在。本文旨在描述成瘾行为的心理和遗传因素(PGA)研究的研究方案,该方案采用综合方法来理解成瘾行为的获得、发展和维持。

方法

进行了一项广泛的全国性研究。从 3003 名青少年中收集数据。通过心理测量上可靠的量表对精神活性物质和行为成瘾进行了全面评估,这些量表还包括与广泛相关心理维度相关的评估。此外,还从参与者中收集了 DNA 样本。

结果

本文介绍了 PGA 研究的详细方法。描述了数据收集程序、仪器以及用于实现研究目标的分析方法。

结论

还讨论了未来计划以及 PGA 研究的潜在贡献。预计该研究将提供一个独特的机会,以测试遗传因素、心理特征和成瘾之间的关联的中介机制和因果途径。

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