变形链球菌gtfB基因的序列分析
Sequence analysis of the gtfB gene from Streptococcus mutans.
作者信息
Shiroza T, Ueda S, Kuramitsu H K
出版信息
J Bacteriol. 1987 Sep;169(9):4263-70. doi: 10.1128/jb.169.9.4263-4270.1987.
Abstract
The nucleotide sequence of the gtfB gene from Streptococcus mutans GS-5, coding for glucosyltransferase I activity, was determined. The gene codes for a strongly hydrophilic protein with a molecular size of 165,800 daltons. The deduced amino acid sequence revealed a typical gram-positive bacterial signal sequence at the NH2 terminus of the protein and 3.5 direct repeating units (each containing 65 amino acids) at the COOH terminus. Nucleotide sequencing of the region immediately downstream from the gtfB gene revealed the presence of a putative gene coding for an extracellular protein. This open reading frame is partially homologous to the gtfB gene.
摘要
测定了变形链球菌GS-5中编码葡糖基转移酶I活性的gtfB基因的核苷酸序列。该基因编码一种分子大小为165,800道尔顿的强亲水性蛋白质。推导的氨基酸序列显示该蛋白质的NH2末端有一个典型的革兰氏阳性细菌信号序列，COOH末端有3.5个直接重复单元（每个包含65个氨基酸）。对gtfB基因紧邻下游区域的核苷酸测序显示存在一个推定的编码细胞外蛋白的基因。这个开放阅读框与gtfB基因部分同源。
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