Wang Shenghang, Luo Jie, Zhang Zhihao, Dong Dandan, Shen Ying, Fang Yanwen, Hu Lijiang, Liu Mengyu, Dai Chengfu, Peng Songlin, Fang Zhicai, Shang Peng
School of Life Sciences, Northwestern Polytechnical University Xi'an 710072, Shaanxi, China.
Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University Xi'an 710072, Shaanxi, China.
Am J Cancer Res. 2018 Oct 1;8(10):1933-1946. eCollection 2018.
Ferroptosis is an iron depend cell death which caused by lipid peroxidation. Abnormal iron metabolism and high intracellular iron content are the characteristics of most cancer cells. Iron is a promoter of cell growth and proliferation. However, iron also could take part in Fenton reaction to produce reactive oxygen species (ROS). The intercellular ROS could induce lipid peroxidation, which is necessary for ferroptosis. Iron metabolism mainly includes three parts: iron uptake, storage and efflux. Therefore, iron metabolism-related genes could regulate intercellular iron content and status, which can be involved ferroptosis. In recent years, the application of nanoparticles in cancer therapy research has become more and more extensive. The iron-based nanoparticles (iron-based NPs) can release ferrous (Fe) or ferric (Fe) in acidic lysosomes and inducing ferroptosis. Magnetic field is widely used in the targeted concentration of iron-based NPs related disease therapy. Furthermore, multiple studies showed that magnetic fields can inhibit cancer cell proliferation by promoting intracellular ROS production. Herein, we focus on the relationship of between ferroptosis and iron metabolism in cancer cells, the application of nanoparticles and magnetic field in inducing ferroptosis of cancer cells, and trying to provide new ideas for cancer treatment research.
铁死亡是一种由脂质过氧化引起的铁依赖性细胞死亡。异常的铁代谢和细胞内高铁含量是大多数癌细胞的特征。铁是细胞生长和增殖的促进剂。然而，铁也可参与芬顿反应以产生活性氧（ROS）。细胞内ROS可诱导脂质过氧化，这是铁死亡所必需的。铁代谢主要包括三个部分：铁摄取、储存和外流。因此，铁代谢相关基因可调节细胞内铁含量和状态，这可能与铁死亡有关。近年来，纳米颗粒在癌症治疗研究中的应用越来越广泛。铁基纳米颗粒（铁基NPs）可在酸性溶酶体中释放亚铁（Fe）或铁离子（Fe）并诱导铁死亡。磁场广泛应用于铁基NPs相关疾病治疗的靶向富集。此外，多项研究表明，磁场可通过促进细胞内ROS产生来抑制癌细胞增殖。在此，我们重点关注癌细胞中铁死亡与铁代谢之间的关系、纳米颗粒和磁场在诱导癌细胞铁死亡中的应用，并试图为癌症治疗研究提供新思路。
