Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Virus Res. 2019 Jan 15;260:7-11. doi: 10.1016/j.virusres.2018.11.003. Epub 2018 Nov 10.
During 2017, a G4P[6] group A rotavirus strain was identified in the feces of an Italian child hospitalized for acute gastroenteritis in Southern Italy. Nucleotide sequencing of the 11 genomic segments, revealed the G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analyses of the gene segments investigated revealed high nucleotide sequence identities with G4P[6] RVA strains detected previously in pigs and in humans. The human strains related to the Italian G4P[6] were mainly reported from Asia, and were detected after an inter-species transmission event from swine. This study reports the genotyping and phylogenetic analysis of a G4P[6] RVA strain presenting a genomic constellation never detected before in Italy. In addition, this strain was able to cause AGE symptoms in a healthy child, successively hospitalized. The molecular characterization suggested zoonotic origin and inter-species transmission of this strain from swine, living open the possibility of its importation from abroad.
2017 年，在意大利南部因急性肠胃炎住院的一名意大利儿童的粪便中发现了一株 G4P[6]组 A 轮状病毒。对 11 个基因组片段的核苷酸测序显示，该病毒具有 G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 基因型组合。对所研究的基因片段的系统进化分析显示，与之前在猪和人类中检测到的 G4P[6] RVA 株具有很高的核苷酸序列同一性。与意大利 G4P[6]相关的人类株主要来自亚洲，是在猪与人类之间发生物种间传播事件后检测到的。本研究报告了一株 G4P[6] RVA 株的基因分型和系统进化分析，该株具有意大利以前从未检测到的基因组组合。此外，该毒株能够引起健康儿童的 AGE 症状，并随后住院。分子特征表明该毒株具有从猪传播的动物源和种间传播的特性，这增加了其从国外输入的可能性。
