College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Jiangsu Key Laboratory for Chinese Material Medica Processing, Nanjing, China.
Nat Prod Res. 2020 May;34(10):1345-1351. doi: 10.1080/14786419.2018.1514399. Epub 2018 Nov 19.
Two new neoclerodane diterpenoids, barbatin F (), barbatin G () together with four known compounds, scutebata A (), scutebata B (), scutebata C () and scutebata P () were isolated from the whole plant of D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound and showed weak cytotoxic activities against HCT-116 colon cancer cell lines with IC value of 44.3, 32.3 μM, respectively, while compound and exhibited moderate cytotoxic activities against four tested human cancer cell lines with IC values of 5.31～28.5 μM.
从 D.Don 的全株植物中分离得到了两个新的新克氏二萜类化合物，巴塔丁 F ()和巴塔丁 G ()，以及四个已知化合物，scutebata A ()、scutebata B ()、scutebata C ()和 scutebata P ()。根据光谱研究确定了它们的结构。对选定的化合物对 LoVo、SMMC-7721、HCT-116 和 MCF-7 癌细胞系的体外细胞毒性进行了评估，化合物 和 对 HCT-116 结肠癌细胞系表现出微弱的细胞毒性活性，IC 值分别为 44.3 和 32.3 μM，而化合物 和 对四种测试的人类癌细胞系表现出中等的细胞毒性活性，IC 值为 5.31-28.5 μM。
