1 Department of Internal Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
2 Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Exp Biol Med (Maywood). 2019 Apr;244(6):505-513. doi: 10.1177/1535370218818175. Epub 2018 Dec 12.
The heterogeneity of the renal disease, therapeutic interventions, and the original cause of the renal failure, all directly affect the microbiota. We delineate in this report the direct effect of decreased renal function on the bacterial composition following stringent criteria to eliminate the possibilities of other confounding factors and dissect the direct effects of the uremic milieu. We analyzed the microbiome following three different approaches to further evaluate the effects of mild, moderate and advanced renal insufficiency on the microbiome. We also present here a detailed functional analysis of the projected altered pathways secondary to changes in the microbiome composition.
肾脏疾病的异质性、治疗干预以及肾衰竭的原始病因都直接影响着微生物组。我们根据严格的标准，排除了其他混杂因素的可能性，并剖析了尿毒症环境对细菌组成的直接影响，在本报告中阐述了肾功能下降对细菌组成的直接影响。我们采用三种不同的方法来分析微生物组，以进一步评估轻度、中度和重度肾功能不全对微生物组的影响。此外，我们还对微生物组组成变化导致的潜在改变途径进行了详细的功能分析。
