Species of are endophytic, plant pathogenic or saprobic, and associated with a wide range of host plants. Recent molecular studies that have attempted to address familial and generic boundaries of fungi belonging to were based on a limited number of samples and DNA loci. The taxonomy of this group of fungi is therefore still not fully resolved. The aim of the present study is to provide a natural classification for the based on multi-locus phylogenetic analyses, using LSU, ITS, , and loci, in combination with morphological data. A total of 30 well-supported monophyletic clades in are recognised, representing 23 known and seven new genera. Typifications are proposed for the type species of five genera (, , , and ) to stabilise the application of these names. Furthermore, and are synonymised under , and the generic circumscriptions of , , , , , , , and are emended. A total of 51 new species, one and 15 combinations are introduced.