El-Sheekh Mostafa M, El-Kassas Hala Y
Botany Department Faculty of Science, Tanta University, Egypt.
National Institute of Oceanography and Fisheries, Marine Environmental Division, Hydrobiology Laboratory, Alexandria, Egypt.
J Genet Eng Biotechnol. 2016 Dec;14(2):299-310. doi: 10.1016/j.jgeb.2016.09.008. Epub 2016 Oct 6.
The spreading of infectious diseases and the increase in incidence of drug resistance among pathogens have made the search for new antimicrobials inevitable, similarly is the cancer disease. Nowadays, there is a growing need for biosynthesized nanoparticles (NPs) as they are one of the most promising and novel therapeutic agents of biological origin. The unique physicochemical properties of the nano silver (Ag-NPs) as well as nano gold (Au-NPs) when combined with the growth inhibitory capacity against microbes lead to an upsurge in the research on NPs and their potential application as antimicrobials. The phytochemicals of marine algae that include hydroxyl, carboxyl, and amino functional groups can serve as effective metal reducing agents and as capping agents to provide a robust coating on the metal NPs. The biosynthesis of Ag-NPs and Au-NPs using green resources is a simple, environmentally friendly, pollutant-free and low-cost approach. The biosynthesized NPs using algae exerted an outstanding antimicrobial and cytotoxic effect.
传染病的传播以及病原体耐药性发生率的增加使得寻找新型抗菌药物成为必然,癌症疾病亦是如此。如今,对生物合成纳米颗粒(NPs)的需求日益增长,因为它们是最具前景的新型生物源治疗剂之一。纳米银(Ag-NPs)和纳米金(Au-NPs)独特的物理化学性质,再加上它们对微生物的生长抑制能力,使得对NPs及其作为抗菌剂的潜在应用的研究热潮高涨。包括羟基、羧基和氨基官能团在内的海藻植物化学物质可作为有效的金属还原剂和封端剂,为金属纳米颗粒提供坚固的涂层。利用绿色资源生物合成Ag-NPs和Au-NPs是一种简单、环保、无污染且低成本的方法。利用藻类生物合成的纳米颗粒具有出色的抗菌和细胞毒性作用。