Miranda Carolinne Thaísa de Oliveira Fernandes, Duarte Victor Hugo Rezende, Cruz Marina Sampaio de Menezes, Duarte Mychelle Kytchia Rodrigues Nunes, de Araújo Jéssica Nayara Góes, Dos Santos Ayda Maria Quirino Silva, de Oliveira Juliana Marinho, Paiva Maria Sanali Moura Oliveira, Rezende Adriana Augusto, Hirata Mario Hiroyuki, Hirata Rosario Dominguez Crespo, Ribeiro Karla Danielly da Silva, Luchessi André Ducati, Silbiger Vivian Nogueira
Laboratory of Bioanalysis and Molecular Biotechnology, Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Brazil.
Department Cardiology, Onofre Lopes University Hospital, Natal, Brazil.
J Nutr Metab. 2018 Dec 11;2018:6104169. doi: 10.1155/2018/6104169. eCollection 2018.
: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients with coronary artery disease. . Patients with coronary artery disease (=177) aged 30-74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using the Friesinger index (FI). Accordingly, patients were grouped as follows: FI = 0-4 (=90), FI = 5-9 (=50), and FI = 10-15 (=37). Serum levels of vitamins were determined via high-performance liquid chromatography and serum biochemical analysis. . Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0-4). Individuals in this group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups ( < 0.05). Low levels of alpha-tocopherol were more frequent in the FI 0-4 group than that in the other groups (=0.03). No difference was observed between the mean serum retinol levels among the FI-based groups (=0.492), and the low frequency of retinol was consistent among the FI groups (=0.348). . The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensive coronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.
脂溶性维生素在心血管疾病的发病机制和动脉粥样硬化的进展中起重要作用。本研究旨在探讨血清α-生育酚和视黄醇水平与冠心病患者冠状动脉病变程度之间的关系。纳入30 - 74岁首次接受冠状动脉造影的冠心病患者（n = 177）。使用弗里辛格指数（FI）评估冠状动脉病变程度。据此，患者分为以下几组：FI = 0 - 4（n = 90），FI = 5 - 9（n = 50），FI = 10 - 15（n = 37）。通过高效液相色谱法和血清生化分析测定血清维生素水平。基于FI分组的评估显示，50.8%的患者冠状动脉病变程度较低（FI 0 - 4）。该组个体比其他组更年轻，血糖和血清α-生育酚水平更低（P < 0.05）。FI 0 - 4组中α-生育酚水平低的情况比其他组更常见（P = 0.03）。基于FI的各组之间血清视黄醇平均水平未观察到差异（P = 0.492），视黄醇低频率在FI各组中一致（P = 0.348）。α-生育酚水平低与血脂异常可能与动脉粥样硬化的初始事件有关。冠状动脉病变更广泛的患者中α-生育酚水平升高可能是由于维生素E代谢改变和氧化应激增加所致。
