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人类白细胞迁移抑制因子产生过程中的细胞协作

Cellular collaboration in the production of human leucocyte migration inhibition factor.

作者信息

Weisbart R H, Yu D T, Billing R, Fan P T, Clements P J, Paulus H E

出版信息

Immunology. 1978 May;34(5):815-9.

Abstract

The participation of cell subpopulations in the expression of leucocyte migration inhibition factor (LMIF) in response to Concanavalin A and Protein A was evaluated for cells isolated from the peripheral blood of five healthy subjects. LMIF activity could not be attributed to the function of T cells, B enriched cells, or monocytes acting alone, or to a combination of B enriched cells and monocytes. The LMIF response was the result of a collaborative event that occurred between T cells and B enriched cells, or between T cells and monocytes.

摘要

对从五名健康受试者外周血中分离出的细胞,评估了细胞亚群在响应伴刀豆球蛋白A和蛋白A时白细胞迁移抑制因子(LMIF)表达中的参与情况。LMIF活性不能归因于单独作用的T细胞、富含B细胞或单核细胞的功能,也不能归因于富含B细胞和单核细胞的组合。LMIF反应是T细胞与富含B细胞之间,或T细胞与单核细胞之间发生的协同事件的结果。

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