Michaud Morgane, Jouhet Juliette
UMR 5168 CNRS, CEA, INRA, Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, Grenoble, France.
Front Plant Sci. 2019 Jan 15;10:2. doi: 10.3389/fpls.2019.00002. eCollection 2019.
The biogenesis of cellular membranes involves an important traffic of lipids from their site of synthesis to their final destination. Lipid transfer can be mediated by vesicular or non-vesicular pathways. The non-vesicular pathway requires the close apposition of two membranes to form a functional platform, called membrane contact sites (MCSs), where lipids are exchanged. These last decades, MCSs have been observed between virtually all organelles and a role in lipid transfer has been demonstrated for some of them. In plants, the lipid composition of membranes is highly dynamic and can be drastically modified in response to environmental changes. This highlights the importance of understanding the mechanisms involved in the regulation of membrane lipid homeostasis in plants. This review summarizes our current knowledge about the non-vesicular transport of lipids at MCSs in plants and its regulation during stress.
细胞膜的生物合成涉及脂质从合成部位到最终目的地的重要运输过程。脂质转运可通过囊泡或非囊泡途径介导。非囊泡途径需要两个膜紧密并列以形成一个功能性平台，即膜接触位点（MCSs），脂质在该位点进行交换。在过去几十年中，几乎在所有细胞器之间都观察到了膜接触位点，并且已经证明其中一些在脂质转运中发挥作用。在植物中，膜的脂质组成具有高度动态性，并且可以响应环境变化而发生剧烈改变。这凸显了理解植物中膜脂稳态调节机制的重要性。本综述总结了我们目前关于植物中膜接触位点处脂质的非囊泡运输及其在胁迫期间调控的知识。
