School of life science, Anhui University, Hefei, 230039, P.R. China.
School of Applied Sciences and Humanities (NUSASH), National University of Technology, Sector I-12, Islamabad, Pakistan.
Chem Asian J. 2019 Feb 15;14(4):509-526. doi: 10.1002/asia.201801437. Epub 2019 Feb 4.
Zinc is a biocompatible element that exists as the second most abundant transition metal ion and an indispensable trace element in the human body. Compared to traditional metal-organic complexes systems, d metal Zn complexes not only exhibit a large Stokes shift and good photon stability but also possess strong emission and low cytotoxicity with a relatively small molecular weight. The use of Zn complexes has emerged in the last decade as a versatile and convenient tool for numerous biological applications, including bioimaging, molecular and protein recognition, as well as photodynamic therapy. Herein, we review recent developments involving Zn metal complexes applied as specific subcellular compartment imaging probes and their correlated utilizations.
锌是一种生物相容性元素,作为人体中第二丰富的过渡金属离子和必需的微量元素而存在。与传统的金属有机配合物体系相比,d 金属 Zn 配合物不仅表现出较大的斯托克斯位移和良好的光子稳定性,而且具有较强的发光性和低细胞毒性,分子量相对较小。在过去的十年中,Zn 配合物作为一种通用且方便的工具,已经在许多生物应用中得到了应用,包括生物成像、分子和蛋白质识别以及光动力疗法。本文综述了近年来涉及作为特定亚细胞区室成像探针的 Zn 金属配合物的最新进展及其相关应用。