Department of Nutrition, Food, and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
Food Funct. 2019 Feb 20;10(2):1062-1072. doi: 10.1039/c8fo01890a.
Previous research suggests potential for fresh pears as a functional food for promoting cardiometabolic health. The purpose of this randomized, open-label, placebo-controlled, crossover clinical trial was to evaluate the influence of daily fresh pear consumption on blood pressure (primary outcome) and other biomarkers of cardiometabolic health in middle-aged/older adults with metabolic syndrome (MetS). Forty men and women aged 45-65 years with MetS were included and randomly assigned to receive either two medium-sized fresh pears (Pear) or a calorie-matched control drink (Control) per day for each 12-week treatment period, each separated by a 4-week washout period. After 12 weeks of daily fresh pear consumption, systolic blood pressure tended to be reduced (130 ± 2 mmHg vs. 134 ± 2 mmHg at baseline, P = 0.07) and pulse pressure was significantly reduced (51 ± 1 vs. 54 ± 1 at baseline, P < 0.05). At 12 weeks, leptin concentrations were lower in the Pear group than Control (52.5 [7.6, 120.5] ng dL-1vs. 53.4 [5.0, 120.5] ng dL-1, respectively, P < 0.05), and there was a significant group by time interaction (P < 0.05). Leptin concentrations were significantly reduced at 12 weeks compared to baseline in the Pear group (52.5 [7.6, 120.5] ng dL-1vs. 54.8 [6.4, 120.5] ng dL-1 at baseline, P < 0.05) but not in the Control group. Waist circumference was significantly reduced at 12 weeks in the Pear group (107.7 ± 2.0 cm vs. 108.4 ± 2 cm at baseline, P < 0.05) with a trend for a group by time interaction (P < 0.1), and significantly lower in the Pear group than Control (108.1 ± 2.0 cm vs. 108.8 ± 2 cm, P < 0.05) at 6 weeks with a significant group by time interaction (P < 0.05). Conversely, values were significantly increased at 6 weeks (108.8 ± 2 cm vs. 108.3 ± 2.0 cm at baseline, P < 0.05) in the Control group and sustained at 12 weeks. Waist-to-hip ratio was significantly reduced (0.92 ± 0.01 vs. 0.93 ± 0.01 at baseline, P < 0.05) at 12 weeks in the Pear group, and significantly lower than Control at 6 weeks (0.93 ± 0.01 vs. 0.93 ± 0.01, respectively, P < 0.05) and 12 weeks (0.92 ± 0.01 vs. 0.93 ± 0.01, P < 0.05). These findings suggest that daily fresh pear consumption may promote modest improvements in cardiometabolic health in middle-aged/older adults with MetS. This trial was registered at clinicaltrials.gov as NCT02228837.
先前的研究表明，鲜梨具有作为促进心脏代谢健康的功能性食品的潜力。本随机、开放标签、安慰剂对照、交叉临床试验的目的是评估每日食用鲜梨对代谢综合征（MetS）中老年成年人血压（主要结局）和其他心脏代谢健康生物标志物的影响。共有 40 名年龄在 45-65 岁之间患有 MetS 的男性和女性被纳入研究，并随机分配每天接受两个中等大小的鲜梨（梨组）或等量的卡路里匹配对照饮料（对照组），每个治疗期持续 12 周，每个治疗期之间间隔 4 周洗脱期。在 12 周的每日食用鲜梨后，收缩压有下降趋势（130 ± 2 mmHg 与基线相比，134 ± 2 mmHg，P = 0.07），脉压显著降低（51 ± 1 mmHg 与基线相比，54 ± 1 mmHg，P < 0.05）。在 12 周时，梨组的瘦素浓度低于对照组（52.5 [7.6，120.5] ng/dL 与 53.4 [5.0，120.5] ng/dL，分别，P < 0.05），且存在显著的组间时间交互作用（P < 0.05）。与基线相比，梨组在 12 周时的瘦素浓度显著降低（52.5 [7.6，120.5] ng/dL 与 54.8 [6.4，120.5] ng/dL，P < 0.05），但对照组无此变化。在 12 周时，梨组的腰围显著减小（107.7 ± 2.0 cm 与基线相比，108.4 ± 2 cm，P < 0.05），且存在显著的组间时间交互作用（P < 0.1），与对照组相比，梨组的腰围也显著减小（108.1 ± 2.0 cm 与 108.8 ± 2 cm，P < 0.05），且在 6 周时存在显著的组间时间交互作用（P < 0.05）。相反，对照组的腰围在 6 周时显著增加（108.8 ± 2 cm 与基线相比，108.3 ± 2.0 cm，P < 0.05），并持续到 12 周。梨组的腰臀比在 12 周时显著降低（0.92 ± 0.01 与基线相比，0.93 ± 0.01，P < 0.05），且在 6 周时显著低于对照组（0.93 ± 0.01 与 0.93 ± 0.01，分别，P < 0.05）和 12 周时（0.92 ± 0.01 与 0.93 ± 0.01，P < 0.05）。这些发现表明，每日食用鲜梨可能会促进中年/老年代谢综合征患者心脏代谢健康的适度改善。该试验在 clinicaltrials.gov 上注册为 NCT02228837。
