既往登革热免疫力对登革热流行地区寨卡病毒出现的影响。
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.
机构信息
Department of Medicine, University of California, San Francisco, CA, USA.
Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
出版信息
Science. 2019 Feb 8;363(6427):607-610. doi: 10.1126/science.aav6618.
Abstract
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
摘要
在美洲，与寨卡病毒（ZIKV）相关的临床结果已得到充分记录，但该大流行的其他方面，如发病率和危险因素，尚不清楚。我们前瞻性地随访了巴西萨尔瓦多的 1453 名城市居民队列，使用一种测定法测量了针对 ZIKV NS1 抗原的免疫球蛋白 G3（IgG3）反应，我们估计在 2015 年的暴发中，有 73%的人被感染。发病率在空间上存在异质性，在一个跨越 0.17 平方公里的社区内，发病率差异达 3 倍。对登革热病毒的预先存在的高抗体滴度与降低 ZIKV 感染和症状的风险有关。目前存在的寨卡病毒免疫景观可能会影响未来传播的风险。
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