通过中性粒细胞膜包覆纳米颗粒实现姜黄素靶向递送至炎症部位用于急性胰腺炎的治疗。
Inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis.
机构信息
Sichuan Provincial Orthopedic Hospital , Chengdu 610041 , China.
Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy , Sichuan University , Chengdu 610041 , China.
出版信息
Mol Pharm. 2019 Mar 4;16(3):1397-1405. doi: 10.1021/acs.molpharmaceut.8b01342. Epub 2019 Feb 21.
Celastrol (CLT)-loaded PEG-PLGA nanoparticles (NPs/CLT) coated with neutrophil membranes (NNPs/CLT) were explored for the management of acute pancreatitis (AP). PEG-PLGA nanoparticles sized around 150 nm were proven to selectively accumulate in the pancreas in rats with AP. NNPs were found to overcome the blood-pancreas barrier and specifically distributed to the pancreatic tissues. Moreover, NNPs showed more selective accumulation in the pancreas than nanoparticles without any membrane coating in AP rats. Compared to CLT solution and the NPs/CLT group, NNPs/CLT significantly downregulated the levels of serum amylase and pancreatic myeloperoxidase in AP rats. Also, using NNPs as the delivery vehicle significantly reduced the systemic toxicity of CLT in AP rats. Together, these results suggest that NNPs/CLT represent a highly promising delivery vehicle for the targeted therapy of AP.
载姜黄素（CLT）的聚乙二醇-聚乳酸-羟基乙酸共聚物纳米粒（NPs/CLT）用中性粒细胞膜（NNPs/CLT）进行了包被，用于治疗急性胰腺炎（AP）。研究发现，粒径约为 150nm 的 PEG-PLGA 纳米粒在 AP 大鼠中具有选择性胰腺聚集的特性。NNPs 可克服血胰屏障，并特异性分布于胰腺组织。此外，与无任何膜包被的纳米粒相比，NNPs 在 AP 大鼠中的胰腺选择性聚集更高。与 CLT 溶液和 NPs/CLT 组相比，NNPs/CLT 可显著下调 AP 大鼠血清淀粉酶和胰腺髓过氧化物酶的水平。同时，使用 NNPs 作为递送载体可显著降低 AP 大鼠中 CLT 的全身毒性。综上所述，这些结果表明，NNPs/CLT 是一种很有前途的治疗 AP 的靶向给药载体。
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