从 和 的果实中得到的新的环烯醚萜衍生物及其神经保护活性。
New Iridoid Derivatives from the Fruits of and Their Neuroprotective Activities.
机构信息
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
出版信息
Molecules. 2019 Feb 11;24(3):625. doi: 10.3390/molecules24030625.
Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of . Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.
从 Cornus officinalis 的乙醇提取物中分离得到三种以前未描述的环烯醚萜类化合物，分别命名为 cornusfurals A⁻C。通过包括一维和二维核磁共振、紫外光谱、红外光谱和质谱在内的光谱方法阐明了它们的结构。通过测量皮质酮诱导的 PC12 细胞损伤来评估其神经保护活性。结果表明，cornusfural B 可降低皮质酮诱导的 PC12 细胞损伤，与模型细胞相比。
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