Turk J Med Sci. 2019 Feb 11;49(1):245-248. doi: 10.3906/sag-1804-68.
BACKGROUND/AIM: In this study, our aim was to investigate the neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes, and the relationship between N/L ratio and insulin resistance (IR) in obesity.
Ninety-six patients and 40 healthy controls were included in this study. Patients’ blood glucose levels, insulin levels, and hemogram parameters upon 8 h of fasting were determined. Body mass index (BMI) and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) values were calculated.
Neutrophil numbers were found to be higher among obese patients with IR than among non-IR obese patients. The N/L ratio was, moreover, found to be higher among obese patients with IR when compared to non-IR obese patients. A positive correlation was found between insulin resistance and both neutrophil and WBC counts. Positive correlations were also found between insulin levels and the N/L ratio, WBC counts, and neutrophil counts
In our study, leukocyte numbers and subtypes were determined to be higher among obese individuals than among healthy individuals. The N/L ratio was increased significantly only among obese patients with IR. Further studies are needed in order to better demonstrate the relationship between the N/L ratio and IR/inflammation.
背景/目的：本研究旨在探讨肥胖患者中性粒细胞/淋巴细胞（N/L）比值、白细胞及其亚型的变化与胰岛素抵抗（IR）的关系。
本研究纳入了 96 例患者和 40 例健康对照者。测定了患者空腹 8 小时后的血糖水平、胰岛素水平和血常规参数。计算了体重指数（BMI）和稳态模型评估-胰岛素抵抗（HOMA-IR）值。
与非胰岛素抵抗性肥胖患者相比，IR 肥胖患者的中性粒细胞数量更高。而且，与非胰岛素抵抗性肥胖患者相比，IR 肥胖患者的 N/L 比值更高。胰岛素抵抗与中性粒细胞和白细胞计数呈正相关。胰岛素水平与 N/L 比值、白细胞计数和中性粒细胞计数也呈正相关。
在本研究中，与健康个体相比，肥胖个体的白细胞数量和亚型更高。只有在胰岛素抵抗性肥胖患者中，N/L 比值才显著增加。需要进一步的研究来更好地证明 N/L 比值与 IR/炎症之间的关系。
