Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Cell Host Microbe. 2019 Feb 13;25(2):184-194. doi: 10.1016/j.chom.2019.01.009.
Bacteria are under constant attack from bacteriophages (phages), bacterial parasites that are the most abundant biological entity on earth. To resist phage infection, bacteria have evolved an impressive arsenal of anti-phage systems. Recent advances have significantly broadened and deepened our understanding of how bacteria battle phages, spearheaded by new systems like CRISPR-Cas. This review aims to summarize bacterial anti-phage mechanisms, with an emphasis on the most recent developments in the field.
细菌不断受到噬菌体（phages）的攻击，噬菌体是地球上最丰富的生物实体，是细菌的寄生虫。为了抵抗噬菌体的感染，细菌进化出了令人印象深刻的抗噬菌体系统。最近的进展极大地拓宽和深化了我们对细菌与噬菌体斗争的理解，CRISPR-Cas 等新系统起到了引领作用。这篇综述旨在总结细菌抗噬菌体的机制，并重点介绍该领域的最新进展。
