Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, Denmark.
CP Kelco ApS, Ved Banen 16, 4623 Lille Skensved, Denmark.
FEMS Microbiol Lett. 2019 Feb 1;366(4). doi: 10.1093/femsle/fnz029.
The increasing efforts to substitute antibiotics and improve animal health combined with the acknowledgement of the role of gut microbiota in health have led to an elevated interest in the understanding on how fibre with prebiotic potential, such as pectin, can improve animal growth and health via direct or gut microbiota mediated effects. Various reports exist on the antiviral and antibacterial effects of pectin, as well as its potency as a modulator of the immune response and gut microbial community. Comprehensive insights into the potential of pectin to improve animal growth and health are currently still hampered by heterogeneity in the design of studies. Studies differ with regard to the dosage, molecular structure and source of the pectin implemented, as well as concerning the set of investigations of its effects on the host. Harmonisation of the study design including an in-depth analysis of the gut microbial community and its metabolome will aid to extract information on how pectin can impact growth and overall animal health. Studies with an increased focus on pectin structure such as on pectin-derived rhamnogalacturonan I (RG-I) are just starting to unravel pectin-structure-related effects on mammalian health.
为了替代抗生素并改善动物健康，人们付出了越来越多的努力，同时人们也认识到了肠道微生物群在健康中的作用，这使得人们对膳食纤维（如果胶）通过直接或肠道微生物群介导的作用来改善动物生长和健康的机制产生了浓厚的兴趣。果胶具有抗病毒和抗菌作用，以及作为免疫反应和肠道微生物群落调节剂的功效，这方面已有很多相关报道。然而，果胶在改善动物生长和健康方面的潜力的全面认识目前仍然受到研究设计的异质性的阻碍。研究在果胶的用量、分子结构和来源，以及对其对宿主影响的一系列研究方面存在差异。通过协调研究设计，包括对肠道微生物群及其代谢组进行深入分析，将有助于提取有关果胶如何影响生长和整体动物健康的信息。越来越多关注果胶结构的研究，例如果胶衍生的鼠李半乳糖醛酸聚糖 I（RG-I）的研究，刚刚开始揭示果胶结构对哺乳动物健康的相关影响。
