Darren G. Candow, PhD, Professor and Associate Dean-Graduate Studies and Research, Faculty of Kinesiology and Health Studies, 3737 Wascana Parkway, University of Regina, Regina SK Canada, S4S 0A2,
J Nutr Health Aging. 2019;23(3):281-285. doi: 10.1007/s12603-018-1148-8.
This study compared the effects of different creatine supplementation dosages, independent of resistance training, on aging muscle performance and functionality.
Using a double-blind, repeated measures design, participants were randomized to one of three groups: Creatine-High (CR-H; n=11; 0.3 g/kg/day of creatine + 0.1 g/kg/day of maltodextrin), Creatine-Moderate (CR-M: n=11; 0.1 g/kg/day of creatine + 0.3 g/kg/day of maltodextrin) or Placebo (PLA; n=11; 0.4 g/kg/day of maltodextrin) for 10 consecutive days.
The primary dependent variables measured at baseline and after supplementation included muscle strength (1-repetition maximum leg press, chest press, hand-grip), muscle endurance (leg press and chest press; maximal number of repetitions performed for 1 set at 80% and 70% baseline 1-repetition maximum respectively), and physical performance (dynamic balance).
There was a significant increase over time for muscle strength (Leg press: CR-H pre 161.5 ± 55.1 kg, post 169.2 ± 59.2 kg; CR-M pre 145.2 ± 47.7 kg, post 151.7 ± 45.0 kg; PLA pre 163.7 ± 51.5 kg, post 178.2 ± 65.6 kg, p = 0.001; Chest press: CR-H pre 57.0 ± 26.2 kg, post 58.8 ± 28.0 kg; CR-M pre 54.5 ± 27.9 kg, post 56.8 ± 30.1 kg; PLA pre 55.1 ± 26.9 kg, post 58.5 ± 30.1 kg, p = 0.001) and endurance (Leg press: CR-H pre 17.1 ± 6.0 reps, post 21.0 ± 7.2 reps; CR-M pre 24.1 ± 11.6 reps, post 29.1 ± 17.0 reps; PLA pre 23.8 ± 9.7 reps, post 29.5 ± 11.9 reps, p = 0. 001; Chest press: CR-H pre 15.6 ± 2.7 reps, post 18.9 ± 2.7 reps; CR-M pre 18.0 ± 5.0 reps, post 19.9 ± 7.1 reps; PLA pre 20.5 ± 6.2 reps, post 21.6 ± 5.5 reps, p = 0. 001), with no other differences.
Short-term creatine supplementation, independent of dosage and resistance training, has no effect on aging muscle performance.
本研究比较了不同剂量的肌酸补充剂（独立于抗阻训练）对衰老肌肉性能和功能的影响。
采用双盲、重复测量设计，将参与者随机分为三组：肌酸高剂量组（CR-H；n=11；0.3 g/kg/天肌酸+0.1 g/kg/天麦芽糊精）、肌酸中剂量组（CR-M：n=11；0.1 g/kg/天肌酸+0.3 g/kg/天麦芽糊精）或安慰剂组（PLA；n=11；0.4 g/kg/天麦芽糊精），连续 10 天。
在基线和补充后测量的主要因变量包括肌肉力量（1 次重复最大腿举、卧推、握力）、肌肉耐力（腿举和卧推；分别为 1 组 80%和 70%基线 1 次重复最大重复次数）和身体表现（动态平衡）。
肌肉力量随着时间的推移显著增加（腿举：CR-H 前 161.5 ± 55.1 公斤，后 169.2 ± 59.2 公斤；CR-M 前 145.2 ± 47.7 公斤，后 151.7 ± 45.0 公斤；PLA 前 163.7 ± 51.5 公斤，后 178.2 ± 65.6 公斤，p=0.001；卧推：CR-H 前 57.0 ± 26.2 公斤，后 58.8 ± 28.0 公斤；CR-M 前 54.5 ± 27.9 公斤，后 56.8 ± 30.1 公斤；PLA 前 55.1 ± 26.9 公斤，后 58.5 ± 30.1 公斤，p=0.001）和耐力（腿举：CR-H 前 17.1 ± 6.0 次，后 21.0 ± 7.2 次；CR-M 前 24.1 ± 11.6 次，后 29.1 ± 17.0 次；PLA 前 23.8 ± 9.7 次，后 29.5 ± 11.9 次，p=0.001；卧推：CR-H 前 15.6 ± 2.7 次，后 18.9 ± 2.7 次；CR-M 前 18.0 ± 5.0 次，后 19.9 ± 7.1 次；PLA 前 20.5 ± 6.2 次，后 21.6 ± 5.5 次，p=0.001），其他方面没有差异。
短期肌酸补充剂（独立于剂量和抗阻训练）对衰老肌肉性能没有影响。
