a Department of Medical Biotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences , Tehran , Iran.
b Imam Khomeini Hospital Complex, Neuroscience Institute , Tehran University of Medical Sciences , Tehran , Iran.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):455-461. doi: 10.1080/21691401.2018.1553786.
Hepatitis B virus (HBV) infection is one of the major health issues in the world presently with high tendency of leading to hepatocarcinoma, cirrhosis, and liver cancer, especially if not properly managed. It has been estimated that there are about 2 billion people with a serological profile of HBV infection, and 360 million patients worldwide living with chronic HBV-associated liver disease, hence the need to find an efficient and precise diagnosis technique to drive a robust treatment for Hepatitis B virus cannot be over emphasized. The emergence of analytical device like biosensor which combines biological and physicochemical element to detect HBV in screened samples has been very helpful in providing a timely intervention to tame this virus. This review focuses on the current state of biosensor researches with respect to various in-depth application of gold nanoparticle for the detection of hepatitis B virus (HBV).
乙型肝炎病毒（HBV）感染是目前全球主要的健康问题之一，有很高的倾向导致肝癌、肝硬化和肝癌，特别是如果不加以适当管理。据估计，约有 20 亿人具有乙型肝炎病毒感染的血清学特征，全球有 3.6 亿人患有慢性乙型肝炎病毒相关肝病，因此需要找到一种高效、精确的诊断技术，为乙型肝炎病毒提供强有力的治疗。生物传感器等分析设备的出现，结合了生物和物理化学元素来检测筛选样本中的 HBV，这对提供及时干预以控制这种病毒非常有帮助。本综述重点介绍了生物传感器研究的现状，以及金纳米粒子在乙型肝炎病毒（HBV）检测中的各种深入应用。
