Asherson R A, Mackay I R, Harris E N
Br Heart J. 1986 Aug;56(2):190-3. doi: 10.1136/hrt.56.2.190.
From the age of 17 a young man had recurrent venous thrombosis, with pulmonary embolism on two occasions. Laboratory investigations showed increased DNA binding, thrombocytopenia, positive antinuclear antibodies, and immunoglobulin A deficiency. A plasminogen activator deficiency was suspected because the euglobulin lysis time was considerably prolonged. Variant lupus was diagnosed. He had a severe myocardial infarct at the age of 20 and subsequent investigations showed the presence in serum of the lupus anticoagulant and antibodies to cardiolipin. The presence of these antiphospholipid antibodies explains the features of his illness and establishes that this case fits into a subset of systemic lupus erythematosus characterised by thrombotic events.
一名年轻男性从17岁起反复发生静脉血栓形成，并有两次肺栓塞。实验室检查显示DNA结合增加、血小板减少、抗核抗体阳性和免疫球蛋白A缺乏。由于优球蛋白溶解时间显著延长，怀疑存在纤溶酶原激活物缺乏。诊断为变异型狼疮。他在20岁时发生了严重心肌梗死，随后的检查显示血清中存在狼疮抗凝物和抗心磷脂抗体。这些抗磷脂抗体的存在解释了他的疾病特征，并确定该病例属于以血栓形成事件为特征的系统性红斑狼疮的一个亚型。
