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2
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本文引用的文献

1
Strategy of prevention: lessons from cardiovascular disease.预防策略：心血管疾病的经验教训。
Br Med J (Clin Res Ed). 1981 Jun 6;282(6279):1847-51. doi: 10.1136/bmj.282.6279.1847.
2
Total and cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for five years.对黑人和白人男性进行了为期五年的随访，研究吸烟、血清胆固醇浓度和舒张压与总死亡率及心血管死亡率之间的关系。
Am Heart J. 1984 Sep;108(3 Pt 2):759-69. doi: 10.1016/0002-8703(84)90669-0.
3
Cardiorespiratory disease and diabetes among middle-aged male Civil Servants. A study of screening and intervention.中年男性公务员的心肺疾病和糖尿病。一项筛查与干预研究。
Lancet. 1974 Mar 23;1(7856):469-73. doi: 10.1016/s0140-6736(74)92783-4.

血浆胆固醇浓度与冠心病死亡：白厅研究的10年结果

Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study.

作者信息

Rose G, Shipley M

出版信息

Br Med J (Clin Res Ed). 1986 Aug 2;293(6542):306-7. doi: 10.1136/bmj.293.6542.306.

DOI:10.1136/bmj.293.6542.306
PMID:3089495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1340986/
Abstract

Ten year mortality from coronary heart disease in 17,718 middle aged men was related to their initial plasma cholesterol concentrations. The relative risk of death from coronary heart disease declined with age, but the absolute excess risk did not. The risk gradient was continuous over the whole range of cholesterol concentrations, the lowest mortality being among men with concentrations below the lowest decile. It seems that, as with blood pressure, the average cholesterol concentration in the blood pressure, the average cholesterol concentration in the population is too high: lowest concentrations are prognostically the best. A quarter of all deaths from coronary heart disease related to cholesterol occurred among men with concentrations above the top decile, but 55% occurred among men with concentrations in the middle three fifths of the distribution; this figure of 55% could be reduced only by a policy aimed at lowering concentrations in the whole population.

摘要

17718名中年男性的冠心病十年死亡率与他们最初的血浆胆固醇浓度有关。冠心病死亡的相对风险随年龄下降，但绝对超额风险并未下降。在整个胆固醇浓度范围内，风险梯度是连续的，死亡率最低的是胆固醇浓度低于最低十分位数的男性。似乎与血压一样，人群中的平均胆固醇浓度过高：最低浓度在预后方面是最好的。与胆固醇相关的冠心病死亡病例中，四分之一发生在浓度高于最高十分位数的男性中，但55%发生在浓度处于分布中间五分之三的男性中；只有通过旨在降低整个人群胆固醇浓度的政策，才能降低这55%的比例。