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基于壳聚糖、透明质酸和精氨酸衍生物的新型膜的制备、表征及伤口愈合效果

Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives.

作者信息

Iacob Andreea-Teodora, Drăgan Maria, Ghețu Nicolae, Pieptu Dragoș, Vasile Cornelia, Buron Frédéric, Routier Sylvain, Giusca Simona Elena, Caruntu Irina-Draga, Profire Lenuța

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania.

Department of Pharmaceutical Biotechnologies and Drug Industry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania.

出版信息

Polymers (Basel). 2018 Jun 2;10(6):607. doi: 10.3390/polym10060607.

DOI:10.3390/polym10060607
PMID:30966641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404145/
Abstract

New membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of the arginine derivatives with thiazolidine-4-one scaffold into the polymer matrix was proved by Fourier-transform infrared spectroscopy (FT-IR). The scanning electron microscopy (SEM) revealed a micro-porous structure that is an important characteristic for the treatment of burns, favoring the exudate absorption, the rate of colonization, the cell structure, and the angiogenesis process. The developed polymeric membranes also showed good swelling degree, improved hydrophilicity, and biocompatibility in terms of surface free energy components, which supports their application for tissue regeneration. Moreover, the chitosan-arginine derivatives (CS-6h, CS-6i) and chitosan-hyaluronic acid-arginine derivative (CS-HA-6h) membranes showed good healing effects on the burn wound model induced to rats. For these membranes a complete reepithelialization was observed after 15 days of the experiment, which supports a faster healing process.

摘要

采用离子交联法制备了基于壳聚糖以及含有噻唑烷 - 4 - 酮支架的新型精氨酸衍生物的壳聚糖 - 透明质酸新型膜。傅里叶变换红外光谱（FT - IR）证实了聚合物基质中存在具有噻唑烷 - 4 - 酮支架的精氨酸衍生物。扫描电子显微镜（SEM）显示出一种微孔结构，这是治疗烧伤的一个重要特征，有利于渗出液吸收、定植速率、细胞结构和血管生成过程。所制备的聚合物膜在表面自由能成分方面还表现出良好的溶胀度、改善的亲水性和生物相容性，这支持了它们在组织再生中的应用。此外，壳聚糖 - 精氨酸衍生物（CS - 6h、CS - 6i）和壳聚糖 - 透明质酸 - 精氨酸衍生物（CS - HA - 6h）膜对诱导的大鼠烧伤创面模型显示出良好的愈合效果。在实验15天后观察到这些膜实现了完全的上皮再形成，这支持了更快的愈合过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/4d4036f1ffa5/polymers-10-00607-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/b88e8f187444/polymers-10-00607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/cc264e85d6de/polymers-10-00607-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/f29dca2aacdf/polymers-10-00607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/ad02bd3af5e3/polymers-10-00607-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/5bd2488b414f/polymers-10-00607-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/1f39c2cd9f31/polymers-10-00607-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/34bb875811de/polymers-10-00607-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/4d4036f1ffa5/polymers-10-00607-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/b88e8f187444/polymers-10-00607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/cc264e85d6de/polymers-10-00607-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/f29dca2aacdf/polymers-10-00607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/ad02bd3af5e3/polymers-10-00607-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/5bd2488b414f/polymers-10-00607-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/1f39c2cd9f31/polymers-10-00607-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/34bb875811de/polymers-10-00607-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d2c/6404145/4d4036f1ffa5/polymers-10-00607-g008a.jpg

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本文引用的文献

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2
Cost-Effective Double-Layer Hydrogel Composites for Wound Dressing Applications.用于伤口敷料应用的高性价比双层水凝胶复合材料
Polymers (Basel). 2018 Mar 12;10(3):305. doi: 10.3390/polym10030305.
3
Chitosan membrane dressings toughened by glycerol to load antibacterial drugs for wound healing.经甘油增韧以负载抗菌药物用于伤口愈合的壳聚糖膜敷料。
伤口处理的现代方法
Polymers (Basel). 2023 Sep 4;15(17):3648. doi: 10.3390/polym15173648.
4
In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair.胶原蛋白和壳聚糖支架联合或不联合干细胞用于骨修复的体内评估
J Funct Biomater. 2023 Jul 8;14(7):357. doi: 10.3390/jfb14070357.
5
Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers.抗病毒传递系统的进展及壳聚糖基聚合物和纳米颗粒抗病毒药物和抗病毒载体。
Viruses. 2023 Feb 28;15(3):647. doi: 10.3390/v15030647.
6
Biomaterials Based on Chitosan and Polyvinyl Alcohol as a Drug Delivery System with Wound-Healing Effects.基于壳聚糖和聚乙烯醇的生物材料作为具有伤口愈合作用的药物递送系统
Gels. 2023 Feb 1;9(2):122. doi: 10.3390/gels9020122.
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4
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6
Chitosan: A potential biopolymer for wound management.壳聚糖：一种用于伤口管理的有潜力的生物聚合物。
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7
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8
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