Gilljam H, Malmborg A S, Strandvik B
Thorax. 1986 Aug;41(8):641-6. doi: 10.1136/thx.41.8.641.
The use of sputum cultures to guide the antimicrobial treatment of patients with cystic fibrosis has been questioned. Bacterial growth and antibiotic susceptibility patterns of 33 culture pairs from sputum and contamination free endobronchial swabs from 14 patients with cystic fibrosis were compared. As expected, Pseudomonas aeruginosa of the mucoid and non-mucoid type, Staphylococcus aureus, and Haemophilus influenzae were the organisms most frequently found. Absolute or good agreement was found in 73% of the culture pairs. The accuracy of the sputum cultures improved with the duration of antimicrobial treatment. The extra information gained from the endobronchial culture did not change the antimicrobial strategy from that based on the sputum culture alone. It is concluded that sputum cultures provide accurate information about the bacterial colonisation of the lower respiratory tract in patients with cystic fibrosis and therefore can be trusted both at onset of treatment and during the entire treatment period.
使用痰培养来指导囊性纤维化患者的抗菌治疗受到了质疑。比较了14例囊性纤维化患者的33对痰培养和无污染支气管内拭子的细菌生长及抗生素敏感性模式。正如预期的那样，黏液型和非黏液型铜绿假单胞菌、金黄色葡萄球菌和流感嗜血杆菌是最常发现的微生物。73%的培养对中发现了完全或良好的一致性。痰培养的准确性随着抗菌治疗时间的延长而提高。从支气管内培养获得的额外信息并没有改变仅基于痰培养的抗菌策略。得出的结论是，痰培养提供了关于囊性纤维化患者下呼吸道细菌定植的准确信息，因此在治疗开始时和整个治疗期间都可以信赖。
