Rasoulinezhad Saeed, Yekta Nafiseh Hosseini, Fallah Ehsan
Department of Persian Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Department of Orthopedic and Trauma Surgery, AJA University of Medical Sciences, Tehran, Iran.
J Family Med Prim Care. 2019 Feb;8(2):634-639. doi: 10.4103/jfmpc.jfmpc_423_18.
Chronic low back pain (CLBP) is one the frequent musculoskeletal issues among adults mostly without a specific etiology. In this study, we investigated a traditional Persian remedy for back pain which is based on topical application of a mixture of sesame oil (SO) and white lily (LSM).
The chemical profile, phenol content, and antioxidant activity of the herbal samples were determined using GC-MS, total phenol content (TPC) assay, and DPPH assay, respectively. Clinical efficacy of the herbal samples by a double-blind placebo was examined.
TPC of SO and LSM was 45 ± 5.7 and 68.3 ± 11.2 mg GAE/g oil mixture, respectively. The SO could inhibit 59.7% of free radicals, whereas LSM showed a radical inhibition rate of 74.7% in DPPH assay. LSM could reduce the pain feeling and obtained the lowest pain scores (Oswestry disability index and numeric rating scale) in weeks 4 and 8 of therapy in comparison to other treatment groups (diclofenac gel and SO) and placebo control (Vaseline).
The results implicate the LSM as a novel therapeutic alternative for the therapy of the CLBP.
慢性下腰痛（CLBP）是成年人中常见的肌肉骨骼问题之一，大多无特定病因。在本研究中，我们调查了一种基于局部应用芝麻油（SO）和白百合（LSM）混合物的传统波斯背痛疗法。
分别采用气相色谱-质谱联用（GC-MS）、总酚含量（TPC）测定法和二苯基苦味酰基自由基（DPPH）测定法测定草药样品的化学特征、酚含量和抗氧化活性。通过双盲安慰剂检验草药样品的临床疗效。
SO和LSM的TPC分别为45±5.7和68.3±11.2mg没食子酸当量/g油混合物。在DPPH测定中，SO可抑制59.7%的自由基，而LSM的自由基抑制率为74.7%。与其他治疗组（双氯芬酸凝胶和SO）及安慰剂对照（凡士林）相比，LSM在治疗第4周和第8周可减轻疼痛感觉，并获得最低疼痛评分（奥斯威斯利功能障碍指数和数字评定量表）。
结果表明LSM是治疗CLBP的一种新型治疗选择。
