既往细胞免疫对流感疫苗接种后体外淋巴细胞对病毒抗原反应的影响。
Influence of prior cellular immunity on the in vitro lymphocyte response to virus antigens after influenza vaccination.
作者信息
Briggs W A
出版信息
Infect Immun. 1981 May;32(2):503-7. doi: 10.1128/iai.32.2.503-507.1981.
The in vitro peripheral blood lymphocyte response to specific influenza virus antigens was studied before and 2 weeks after trivalent influenza vaccination of 16 healthy persons. Changes in serum hemagglutination inhibition antibody titers were also determined. An inverse correlation was found between the prevaccination antibody titers and the log2 mean-fold increase in antibody titers after vaccination (r = -0.86, P less than 0.01). An inverse correlation was also found between the prevaccination stimulation index and the ratio of postvaccination to prevaccination stimulation index for each virus strain (A/Victoria, r = -0.48, P less than 0.05; A/USSR, r = -0.55, P less than 0.02; and B/Hong Kong, r = -0.55, P less than 0.02). Similar negative correlations were not consistently found with the nonspecific mitogens phytohemagglutinin, pokeweed mitogen, and concanavalin A. These results suggest that the state of cellular as well as humoral immunity to virus antigens before vaccination influence the magnitude of response after vaccination and that antigen-specific suppressor cell activity may be stimulated by vaccination.
对16名健康人进行三价流感疫苗接种前及接种后2周，研究了其体外外周血淋巴细胞对特定流感病毒抗原的反应。还测定了血清血凝抑制抗体滴度的变化。接种前抗体滴度与接种后抗体滴度的log2平均增加倍数之间呈负相关（r = -0.86，P < 0.01）。对于每种病毒株（A/维多利亚，r = -0.48，P < 0.05；A/苏联，r = -0.55，P < 0.02；以及B/香港，r = -0.55，P < 0.02），接种前刺激指数与接种后刺激指数与接种前刺激指数之比之间也呈负相关。对于非特异性有丝分裂原植物血凝素、商陆有丝分裂原和刀豆球蛋白A，未一致发现类似的负相关。这些结果表明，接种前对病毒抗原的细胞免疫和体液免疫状态会影响接种后的反应程度，并且接种疫苗可能会刺激抗原特异性抑制细胞活性。
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